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O-, N- and S-Methyltransferases

  • C. R. Creveling
  • D. R. Thakker
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 112)

Abstract

The existence of methylation as a metabolic conjugation reaction was first established over a century ago when N-methylpyridinium metabolite was detected by HIS (1887) in dog urine after administration of pyridine. Since then, methyl transfer has been shown as one of the most widely utilized conjugation reactions in nature. A wide variety of endogenous molecules as well as xenobiotics are metabolically transformed by methyl transfer reactions; these molecules include proteins, nucleic acids, phospholipids, catecholamines, steroids, alkyl- and arylamines, and thiols. The transfer of a methyl group to a variety of heteroatoms, such as oxygen, nitrogen, and sulfur, is catalyzed by many methyltransferase enzymes with varying degree of substrate selectivity. It is interesting to note that despite a diversity of enzymes catalyzing the methyl transfer reaction, a common methyl donor is shared by all these enzymes, i.e., S-adenosyl-L-methionine (AdoMet). The O-methylation (Thakker and Creveling 1990; Boudikova et al. 1990; Creveling 1993; Klein et al. 1992), N-methylation (Ansher and Jakoby 1990), and S-methylation (Stevens and Bakke 1990; Hoffman 1993) reactions have been discussed in recent comprehensive reviews.

Keywords

COMT Inhibitor Methyl Transfer COMT Activity Metabolic Inactivation PNMT Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • C. R. Creveling
  • D. R. Thakker

There are no affiliations available

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