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Challenges and Directions for Future Research

  • F. C. Kauffman
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 112)

Abstract

It is clear from material reviewed in the preceding chapters that application of the tools of molecular biology to enzyme reactions catalyzing conjugating and deconjugating enzymes has greatly advanced understanding of the expression and regulation of these important drug-metabolizing systems in a variety of tissues. In addition to better understanding the biology of transferases involved in conjugation of biotic and xenobiotic metabolites, it is clear that various hydrolases such as β-glucuronidase, aryl-sulfatase, amidases, and carboxylesterases have critical functions in the net formation and biological activity of many drug and toxic chemical conjugates. Molecular biological approaches being used to define the genetic regulation and tissue distribution of hydrolases involved in processing chemical conjugates are reviewed in several chapters of this volume, since their role in regulating net conjugate production in intact cells is beginning to be recognized.

Keywords

Drug Conjugate Active Conjugate Acyl Glucuronide Antioxidant Responsive Element Cell BioI 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1994

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  • F. C. Kauffman

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