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Roles of Uridine Diphosphate Glucuronosyltransferases in Chemical Carcinogenesis

  • Chapter
Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 112))

Abstract

Roles of isozymes of the uridine diphosphate (UDP)-glueuronosyltransferase (UGT) family (EC 2.4.1.17) will be discussed in the light of recent concepts of carcinogenesis. Glucuronides may be transport forms of carcinogens that play a major role in determining the target of carcinogenicity, for example, in urinary bladder or colon epithelium. Roles of UGT isozymes can be best appreciated in the context of overall xenobiotic metabolism. In addition to preventing accumulation of lipid-soluble compounds, “xenobiotic” or drugmetabolizing enzymes may also fulfill important roles in controlling endogenous signal compounds such as hormones (Nebert 1991).

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  1. K. W. Bock
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  2. W. Lilienblum
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Bock, K.W., Lilienblum, W. (1994). Roles of Uridine Diphosphate Glucuronosyltransferases in Chemical Carcinogenesis. In: Kauffman, F.C. (eds) Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity. Handbook of Experimental Pharmacology, vol 112. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78429-3_14

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