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The Uridine Diphosphate Glucuronosyltransferase Multigene Family: Function and Regulation

  • Chapter
Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 112))

Abstract

Glucuronidation is a major detoxication pathway in all vertebrates examined, from the most primitive (fish; Clarke et al. 1991) to the most evolved (man; Dutton 1980) and accounts for most of the detoxified material in bile and urine (Dutton 1980).

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  1. D. J. Clarke
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  2. B. Burchell
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  1. Laboratory for Cellular and Biochemical Toxicology College of Pharmacy, Rutgers University, Kilmer Campus 41 Gordon Road, Piscataway, NJ, 08854, USA

    Frederick C. Kauffman Ph.D. (Director) (Director)

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Clarke, D.J., Burchell, B. (1994). The Uridine Diphosphate Glucuronosyltransferase Multigene Family: Function and Regulation. In: Kauffman, F.C. (eds) Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity. Handbook of Experimental Pharmacology, vol 112. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78429-3_1

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  • DOI: https://doi.org/10.1007/978-3-642-78429-3_1

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