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Rationale to Treat

  • Chapter
Principles and Treatment of Lipoprotein Disorders

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 109))

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Abstract

The weight of evidence from primary and secondary prevention clinical trials indicates that reduction of low-density lipoprotein cholesterol (LDLC) levels by diets, drugs, or other means can decrease the incidence of fatal and nonfatal myocardial infarction. A series of angiographic trials have demonstrated that reduced mortality and morbidity from LDL-C reduction are attributable, at least in part, to stabilization and regression of coronary atherosclerosis in both native vascular beds and venous bypass grafts. These studies provide the rationale for treatment of hyperlipoproteinemia with the goal of preventing coronary heart disease. Evidence from human clinical trials is supported by an extensive series of experiments in atherosclerotic animals of many species, including nonhuman primates. This review of treatment rationale summarizes evidence from human mortality and morbidity-based trials, human angiographic trials, and experimental animal models.

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Authors
  1. D. H. Blankenhorn
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  2. H. N. Hodis
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Editors and Affiliations

  1. Klinisches Institut für Herzinfarktforschung an der Medizinischen Universitätsklinik, University of Heidelberg, Bergheimer Straße 58, D-69115, Heidelberg, Germany

    Gotthard Schettler

  2. School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism, University of Heidelberg, Bergheimer Straße 58, D-69115, Heidelberg, Germany

    Andreas J. R. Habenicht

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© 1994 Springer-Verlag Berlin Heidelberg

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Blankenhorn, D.H., Hodis, H.N. (1994). Rationale to Treat. In: Schettler, G., Habenicht, A.J.R. (eds) Principles and Treatment of Lipoprotein Disorders. Handbook of Experimental Pharmacology, vol 109. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78426-2_8

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  • DOI: https://doi.org/10.1007/978-3-642-78426-2_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78428-6

  • Online ISBN: 978-3-642-78426-2

  • eBook Packages: Springer Book Archive

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