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Principles and Treatment of Lipoprotein Disorders pp 53–87Cite as

Lipoprotein Receptors

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 109))

Abstract

Polypeptide-binding receptors in mammalian plasma membranes may be divided into two categories, class I and class II receptors (Kaplan 1981). Class II receptors mediate the cellular uptake and delivery of ligands to intracellular sites, generally to lysosomes for degradation, and then recycle to the cell surface. In contrast, class I receptors are characterized by their ability to mediate signal transduction. Lipoprotein receptors fall mainly into the class II category. Since the low-density lipoprotein (LDL) receptor was cloned and sequenced in 1984, the structures of two other receptors have also been determined.

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Authors
  1. W. J. S. de Villiers
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  2. G. A. Coetzee
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  3. D. R. van der Westhuyzen
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Editors and Affiliations

  1. Klinisches Institut für Herzinfarktforschung an der Medizinischen Universitätsklinik, University of Heidelberg, Bergheimer Straße 58, D-69115, Heidelberg, Germany

    Gotthard Schettler

  2. School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism, University of Heidelberg, Bergheimer Straße 58, D-69115, Heidelberg, Germany

    Andreas J. R. Habenicht

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© 1994 Springer-Verlag Berlin Heidelberg

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de Villiers, W.J.S., Coetzee, G.A., van der Westhuyzen, D.R. (1994). Lipoprotein Receptors. In: Schettler, G., Habenicht, A.J.R. (eds) Principles and Treatment of Lipoprotein Disorders. Handbook of Experimental Pharmacology, vol 109. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78426-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-78426-2_3

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