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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 109))

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Abstract

Plasma lipids are transported by lipoproteins composed of several classes of lipids (including cholesterol, triglycerides, and phospholipids) and proteins designated apolipoproteins. Our understanding of the role of lipoproteins and apolipoproteins in lipid transport has markedly increased over the last two decades. The roles of lipoprotein receptors, enzymes, and apolipoproteins in lipoprotein metabolism have been elucidated, and this new information provides a conceptual framework for the understanding of lipid transport in normal subjects and dyslipoproteinemic patients.

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References

  • Alaupovic P (1972) Conceptual development of the classification systems of plasma lipoproteins. Protides of the biological fluids. Proceedings of the 19th colloquium 9–19

    Google Scholar 

  • Armstrong VW, Cremer P, Eberle E, Manke A, Schulze F, Wieland H, Kreuzer H, Seidel D (1986) The association between serum Lp(a) concentrations and angiographically assessed coronary atherosclerosis. Dependence on serum LDL levels. Atherosclerosis 62:249–257

    Article  PubMed  CAS  Google Scholar 

  • Azrolan N, Gavish D, Breslow JL (1990) Lp(a) levels correlate inversely with apo(a) size and KIV copy number but not with apo(a) mRNA levels in a cynomolgus monkey model. Circulation 82:III-90

    Google Scholar 

  • Barbaras R, Puchois P, Fruchart JC, Ailhaud G (1987a) Cholesterol efflux from cultured adipose cells is mediated by LpAI particles but not by Lp AI:All particles. Biochem Biophys Res Commun 142:63–69

    Article  CAS  Google Scholar 

  • Barbaras R, Puchois P, Grimaldi P, Barkia A, Fruchart JC, Ailhaud G (1987b) Relationship in adipose cells between the presence of receptor sites for high density lipoproteins and the promotion of reverse cholesterol transport. Biochem Biophys Res Commun 149:545–554

    Article  CAS  Google Scholar 

  • Bekaert ED, Alaupovic P, Knight-Gibson CS, Laux MJ, Pelachyk JM, Norum RA (1991) Characterization of apoA- and apoB-containing lipoprotein particles in a variant of familial apoA-I deficiency with planar xanthoma: the metabolic significance of LP-A-II particles. JLR 32:1587–1599

    CAS  Google Scholar 

  • Berg K, Dahlen G, Frick MH (1974) Lp(a) lipoprotein and pre-betal-lipoprotein in patients with coronary heart disease. Clin Genet 6:230–235

    Article  PubMed  CAS  Google Scholar 

  • Blackhart BD, Ludwig EM, Pierotti VR, Caiati L, Onasch MA, Wallis SC, Powell L, Pease R, Knott TJ, Chu ML, Scott MJ, McCarthy BJ, Levy-Wilson B (1986) Structure of the human apolipoprotein B gene. J Biol Chem 261:15364–15367

    PubMed  CAS  Google Scholar 

  • Brewer HB Jr (1981) Current concepts of the molecular structure and metabolism of human apolipoproteins and lipoproteins. Klin Wochenschr 59:1023–1035

    Article  PubMed  CAS  Google Scholar 

  • Breslow JL (1988) Apolipoprotein genetic variation and human disease. Physiol Rev 68:85–132

    PubMed  CAS  Google Scholar 

  • Brewer HB Jr, Zech LA, Gregg RE, Schwartz D, Schaefer EJ (1983) Type III hyperlipoproteinemia: diagnosis, molecular defects, pathology, and treatment. Ann Intern Med 98:623–640

    PubMed  Google Scholar 

  • Brewer HB Jr, Gregg Re, Hoeg JM, Fojo SS (1988) Apolipoproteins and lipoproteins in human plasma: an overview. Clin Chem 34:4–8

    Google Scholar 

  • Brewer HB Jr, Gregg RE, Hoeg JM (1989) Apolipoproteins, lipoproteins, and atherosclerosis. In: Braunwald E (ed) Heart disease: a textbook of cardiovascular medicine, 3rd edn. Saunders, New York, pp 121–144

    Google Scholar 

  • Chen SH, Habib G, Yang CY, Gu ZW, Lee BR, Weng SA, Silberman SR, Cai SJ, Deslypere JP, Rosseneu M, Gotto AM Jr, Li WH, Chan L (1987) Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon. Science 238:363–366

    Article  PubMed  CAS  Google Scholar 

  • Cheung MC, Albers JJ (1984) Characterization of lipoprotein particles isolated by immunoaffinity chromatography. Particles containing A-I and A-II and particles containing A-I but no A-II. J Biol Chem 259:12201–12209

    PubMed  CAS  Google Scholar 

  • Davignon J, Gregg RE, Sing CF (1988) Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 8:1–21

    Article  PubMed  CAS  Google Scholar 

  • Dawson PA, Hofman SL, Van der Westhuyzen DR, Sudhof TC, Brown MS, Goldstein JL (1988) Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Spl. J Biol Chem 263:3372–3379

    PubMed  CAS  Google Scholar 

  • Deeb SS, Cheung MC, Peng R, Wolf AC, Stern R, Albers JJ, Knopp RH (1991) A mutation in the human apolipoprotein A-I gene. Dominant effect on the level and characteristics of plasma high density lipoproteins. J Biol Chem 266:13654–13660

    PubMed  CAS  Google Scholar 

  • Eaton DL, Fless GM, Kohr WJ, McLean JW, Xu QT, Miller CG, Lawn RM, Scanu AM (1987) Partial amino acid sequence of apolipoprotein(a) shows that it is homologous to plasminogen. Proc Natl Acad Sci USA 84:3224–3228

    Article  PubMed  CAS  Google Scholar 

  • Edge SB, Hoeg JM, Triche T, Schneider PD, Brewer HB Jr (1986) Cultured human hepatocytes. Evidence for metabolism of low density lipoproteins by a pathway independent of the classical low density lipoprotein receptor. J Biol Chem 261:3800–3806

    PubMed  CAS  Google Scholar 

  • Eisenberg S (1984) High density lipoprotein metabolism. J Lipid Res 25:1017–1058

    PubMed  CAS  Google Scholar 

  • Fielding CJ, Shore VG, Fielding PE (1972) A protein cofactor of lecithin: cholesterol acyltransferase. Biochem Biophys Res Commun 46:1493–1498

    Article  PubMed  CAS  Google Scholar 

  • Fless GM, Rolih CA, Scanu AM (1984) Heterogeneity of human plasma lipoprotein (a). Isolation and characterization of the lipoprotein subspecies and their apoproteins. J Biol Chem 259:11470–11478

    PubMed  CAS  Google Scholar 

  • Gaubatz JW, Heideman C, Gotto AM Jr, Morrisett JD, Dahlen GH (1983) Human plasma lipoprotein [a]. Structural properties. J Biol Chem 258:4582–4589

    PubMed  CAS  Google Scholar 

  • Glomset JA (1968) The plasma lecithin: cholesterol acyltransferase reaction. J Lipid Res 9:155–167

    PubMed  CAS  Google Scholar 

  • Glomset JA, Janssen ET, Kennedy R, Dobbins J (1966) Role of plasma lecithin: cholesterol acyltransferase in the metabolism of high density lipoproteins. J Lipid Res 7:638–648

    PubMed  CAS  Google Scholar 

  • Gofman JW, deLalla O, Glazier F et al. (1954) The serum lipid transport system in health, metabolic disorders, atherosclerosis, and coronary artery disease. Plasma 2:413–484

    Google Scholar 

  • Goldstein JL, Brown MS (1979) The LDL receptor locus and the genetics of familial hypercholesterolemia. Annu Rev Genet 13:259–289

    Article  PubMed  CAS  Google Scholar 

  • Goldstein JL, Brown MS, Anderson RG, Russell DW, Schneider WJ (1985) Receptor-mediated endocytosis: concepts emerging from the LDL receptor system. Annu Rev Cell Biol 1:1–39

    Article  PubMed  CAS  Google Scholar 

  • Gordon DJ, Rifkind BM (1989) High-density lipoprotein — the clinical limplications of recent studies. N Engl J Med 321:1311–1316

    Article  PubMed  CAS  Google Scholar 

  • Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR (1977) High density lipoprotein as a protective factor against coronary heart disease. The Framingham study. Am J Med 63:707–714

    Article  Google Scholar 

  • Gregg RE, Brewer HB Jr (1988) The role of apolipoprotein E and lipoprotein receptors in modulating the in vivo metabolism of apolipoprotein B-containing lipoproteins in humans. Clin Chem 34:28–32

    Google Scholar 

  • Gregg RE, Zech LA, Schaefer EJ, Brewer HB Jr (1981) Type III hyperlipoproteinemia: defective metabolism of an abnormal apolipoprotein E. Science 211: 584–586

    CAS  Google Scholar 

  • Haberland ME, Fogelman AM (1987) The role of altered lipoproteins in the pathogenesis of atherosclerosis. Am Heart J 113:573–57

    Article  PubMed  CAS  Google Scholar 

  • Havel RJ (1982) Familial dysbetalipoproteinemia. New aspects of pathogenesis and diagnosis. Med Clin North Am 66:441–454

    PubMed  CAS  Google Scholar 

  • Havel RJ, Shore VG, Shore B, Bier DM (1970) Role of specific glycopeptides of human serum lipoproteins in the activation of lipoprotein lipase. Circ Res 27:595–600

    PubMed  CAS  Google Scholar 

  • Herbert PN, Gotto AM Jr, Frederickson DS (1978) Familial lipoprotein deficiency (abetalipoproteinemia, hypobetalipoproteinemia, and Tangier disease). In: Stanberg JB, Wyngaarden JB, Frederickson DS (eds) Metabolic basis of inherited disease. McGraw-Hill, New York, pp 544–588

    Google Scholar 

  • Herz J, Hamann U, Rogne S, Myklebos O, Gausepohl H, Stanley KK (1988) Surface location and high affinity for calcium of a 500 kDa liver membrane protein closely related to the LDL receptor suggest a physiological role as a lipoprotein receptor. EMBO J 7:4119–4127

    PubMed  CAS  Google Scholar 

  • Higuchi K, Hospattankar AV, Law SW, Meglin N, Cortright J, Brewer HB Jr (1988) Human apolipoprotein B (apoB) mRNA: identification of two distinct apoB mRNAs, an mRNA with the apoB-100 sequence and an apoB mRNA containing a premature in-frame translational stop codon, in both liver and intestine. Proc Natl Acad Sci USA 85:1772–1776

    Article  PubMed  CAS  Google Scholar 

  • Hoeg JM, Edge SB, Demosky SJ Jr, Starzl TE, Triche T, Gregg RE, Brewer HB Jr (1986) Metabolism of low-density lipoproteins by cultured hepatocytes from normal and homozygous familial hypercholesterolemic subjects. Biochim Biophys Acta 876:646–657

    PubMed  CAS  Google Scholar 

  • Hospattankar AV, Fairwell T, Ronan R, Brewer HB Jr (1984) Amino acid sequence of human plasma apolipoprotein C-II from normal and hyperlipoproteinemic subjects. J Biol Chem 259:318–322

    PubMed  CAS  Google Scholar 

  • Hospattankar AV, Higuchi K, Law SW, Meglin N, Brewer HB Jr (1987) Identification of a novel in-frame translational stop codon in human intestine apoB mRNA. Biochem Biophys Res Commun 148:279–285

    Article  PubMed  CAS  Google Scholar 

  • Jackson RL, Baker HN, Gilliam EB, Gotto AM Jr (1977) Primary structure of very low density apolipoprotein C-II of human plasma. Proc. Natl Acad Sci USA 74:1942–1945

    Article  CAS  Google Scholar 

  • Jahn CE, Osborne JC Jr, Schaefer EJ, Brewer HB Jr (1983) Activation of the enzymic activity of hepatic lipase by apolipoprotein A-II. Characterization of a major component of high density lipoprotein as the activating plasma component in vitro. Eur J Biochem 131:25–29

    Article  PubMed  CAS  Google Scholar 

  • Kane JP (1983) Apolipoprotein B: structural and metabolic heterogeneity. Annu Rev Physiol 45:637–650

    Article  PubMed  CAS  Google Scholar 

  • Kodama T, Freeman M, Rohrer L, Zabrecky J, Matsudaira P, Krieger M (1990) Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Nature 343:531–535

    Article  PubMed  CAS  Google Scholar 

  • Koschinsky ML, Beisiegel U, Henne-Bruns D, Eaton DL, Lawn RM (1990) Apolipoprotein(a) size heterogeneity is related to variable number of repeat sequences in its mRNA. Biochemistry 29:640–644

    Article  PubMed  CAS  Google Scholar 

  • Kostner G, Alaupovic P (1972) Studies of the composition and structure of plasma lipoproteins. Separation and quantification of the lipoprotein families occurring in the high density lipoproteins of human plasma. Biochemistry 11:3419–3428

    Article  PubMed  CAS  Google Scholar 

  • Kostner GM, Avagaro P, Zazzolato G, Marth E, Bittolo-Bon G, Quinci GB (1981) Lipoprotein Lp(a) and the risk for myocardial infarction. Arteriosclerosis 38:51–61

    Article  CAS  Google Scholar 

  • Lackner KJ, Monge JC, Gregg RE, Hoeg JM, Triche TJ, Law SW, Brewer HB Jr (1986) Analysis of the apolipoprotein B gene and messenger ribonucleic acid in abetalipoproteinemia. J Clin Invest 78:1707–1712

    Article  PubMed  CAS  Google Scholar 

  • LaRosa JC, Levy RI, Herbert P, Lux SE, Fredrickson DS (1970) A specific apoprotein activator for lipoprotein lipase. Biochem Biophys Res Commun 41:57–62

    Article  Google Scholar 

  • Lee RS, Hatch RT (1963) Sharper separation of lipoprotein species by paper electrophoresis in albumin containing buffer. J Lab Clin Med 61:518–528

    Google Scholar 

  • Leppert M, Breslow JL, Wu L, Hasstedt S, O’Connell P, Lathrop M, Williams RR, White R, Lalouel JM (1988) Inference of a molecular defect of apolipoprotein B in hypobetalipoproteinemia by linkage analysis in a large kindred. J Clin Invest 82:847–851

    Article  PubMed  CAS  Google Scholar 

  • Li WH, Tanimura M, Luo CC, Datta S, Chan L (1988) The apolipoprotein multigene family: biosynthesis, structure, structure—function relationships, and evolution. J Lipid Res 29:245–271

    PubMed  CAS  Google Scholar 

  • Loscalzo J (1990) Lipoprotein(a). A unique risk factor for atherothrombotic disease. Arteriosclerosis 10:672–679

    Article  PubMed  CAS  Google Scholar 

  • Mahley RW (1979) Dietary, fat, cholesterol, and accelerated atherosclerosis. Atherosclerosis Rev 5:1–34

    CAS  Google Scholar 

  • Mahley RW, Hui DY, Innerarity TL, Weisgraber KH (1981) Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors. J Clin Invest 68:1197–1206

    CAS  Google Scholar 

  • Mahley RW, Innerarity TL, Rall SC Jr, Weisgraber KH (1984) Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res 25:1277–1294

    PubMed  CAS  Google Scholar 

  • McKnight GL, Reasoner J, Gilbert T, Sundquist KO, Hokland B, McKernan PA, Champagne J, Johnson CJ, Bailey MC, Holly R, O’Hara PJ, Oram JF (1992) Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells. J Biol Chem 267:12131–12141

    PubMed  CAS  Google Scholar 

  • McLean JW, Tomlinson JE, Kuang WJ, Eaton DL, Chen EY, Fless GM, Scanu AM, Lawn RM (1987) cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature 330:132–137

    Article  PubMed  CAS  Google Scholar 

  • Mendez AJ, Oram JF, Bierman EL (1991) Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol. J Biol Chem 266:10104–10111

    PubMed  CAS  Google Scholar 

  • Miles LA, Plow EF (1990) Lp(a): an interloper in the fibrinolytic system. Thromb Haemost 63:331–335

    PubMed  CAS  Google Scholar 

  • Miller GJ, Miller NE (1975) Plasma-high-density-lipoprotein concentration and development of ischaemic heart disease. Lancet 1:16–19

    Article  PubMed  CAS  Google Scholar 

  • Miller NE, Thelle DS, Forde OH, Mjos OD (1977) The Tromso heart-study: high-density lipoproteins and coronary heart-disease: a prospective case-control study. Lancet 1:965–968

    Article  PubMed  CAS  Google Scholar 

  • Mowri H-O, Patsch W, Smith LC, Gotto AM Jr, Patsch JR (1990) Different reactivities of HDL2 subfractions with hepatic lipase. Circulation 82:558

    Google Scholar 

  • Nestruck AC, Niedmann PD, Wieland H, Seidel D (1983) Chromatofocusing of human high density lipoproteins and isolation of lipoproteins A and A-I. Biochim Biophys Acta 753:65–73

    PubMed  CAS  Google Scholar 

  • Norum RA, Lakier JB, Goldstein S, Angel A, Goldberg RB, Block WD, Noffze DK, Dolphin PJ, Edelglass J, Bogorad DD, Alaupovic P (1982) Familial deficiency of apolipoproteins A-I and C-III and precocious coronary-artery disease. N Engl J Med 306:1513–1519

    Article  PubMed  CAS  Google Scholar 

  • Oram JF, Brinton EA, Bierman EL (1983) Regulation of high density lipoprotein receptor activity in cultured human skin fibroblasts and human arterial smooth muscle cells. J Clin Invest 72:1611–1621

    Article  PubMed  CAS  Google Scholar 

  • Osborne JC Jr, Brewer FIB Jr (1977) The plasma lipoproteins. Adv Protein Chem 31:253–337

    Article  PubMed  CAS  Google Scholar 

  • Powell LM, Wallis SC, Pease RJ, Edwards YH, Knott TJ, Scott J (1987) A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine. Cell 50:831–840

    Article  PubMed  CAS  Google Scholar 

  • Puchois P, Kandoussi A, Fievet P, Fourrier JL, Bertrand M, Koren E, Fruchart JC (1987) Apolipoprotein A-I containing lipoproteins in coronary artery disease. Atherosclerosis 68:35–40

    Article  PubMed  CAS  Google Scholar 

  • Rader DJ, Castro G, Zech LA, Fruchart JC, Brewer HB Jr (1991) in vivo metabolism of apolipoprotein A-I on high density lipoprotein particles LpA-I and LpAI, A-II. J Lipid Res 32:1849–1859

    PubMed  CAS  Google Scholar 

  • Rall SC Jr, Weisgraber KH, Mahley RW (1982) Human apolipoprotein E. The complete amino acid sequence. J Biol Chem 257:4171–4178

    PubMed  CAS  Google Scholar 

  • Ross RS, Gregg RE, Law SW, Monge JC, Grant SM, Higuchi K, Triche TJ, Jefferson J, Brewer HB Jr (1988) Homozygous hypobetalipoproteinemia: a disease distinct from abetalipoproteinemia at the molecular level. J Clin Invest 81:590–595

    Article  PubMed  CAS  Google Scholar 

  • Russell DW, Esser V, Hobbs HH (1989) Molecular basis of familial hypercholesterolemia. Arteriosclerosis [Suppl I] 9:1–8

    CAS  Google Scholar 

  • Scanu AM, Landsberger FR (1980) Lipoprotein structure. Ann NY Acad Sci 384:1–436

    Google Scholar 

  • Schaefer EJ, Ordovas JM, Law SW, Ghiselli G, Kashyap ML, Srivastava LS, Heaton WII, Albers JJ, Connor WE, Lindgren FT, Lemeshev Y, Segrest JP, Brewer HB Jr (1985) Familial apolipoprotein A-I and C-III deficiency, variant II. J Lipid Res 26:1089–1101

    PubMed  CAS  Google Scholar 

  • Schmitz G, Lackner K (1989) High density lipoprotein deficiency with xanthomas: a defect in apoA-I synthesis. In: Crepaldi G, Baggio G (eds) Atherosclerosis VIII. Tekno, Rome, pp 399–403

    Google Scholar 

  • Schmitz G, Niemann R, Brennhausen B, Krause R, Assmann G (1985) Regulation of high density lipoprotein receptors in cultured macrophages: role of acyl-CoA: cholesterol acyltransferase. EMBO J 4:2773–2779

    PubMed  CAS  Google Scholar 

  • Schultz JR, Verstuyft JG, Gong EL, Nichols AV, Rubin EM (1992) ApoAI and apoAl + apoAII trangenic mice: a comparison of atherosclerotic susceptibility. Circulation 86:1–472

    Google Scholar 

  • Steinberg D (1983) Lipoproteins and atherosclerosis. A look back and a look ahead. Arteriosclerosis 3:283–301

    Article  PubMed  CAS  Google Scholar 

  • Steinberg D (1991) Antioxidants and atherosclerosis: a current assessment. Circulation 84:1420–1425

    PubMed  CAS  Google Scholar 

  • Strickland DK, Ashcom JD, Williams S, Burgess WH, Migliorini M, Argraves WS (1990) Sequence identity between alpha2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J Biol Chem 265:17401–17404

    PubMed  CAS  Google Scholar 

  • Sudhof TC, Goldstein JL, Brown MS, Russell DW (1985). The LDL receptor gene: a mosaic of exons shared with different proteins. Science 228:815

    Article  PubMed  CAS  Google Scholar 

  • Suzuki N, Fidge N, Nestel P, Yin J (1983) Interaction of serum lipoproteins with the intestine. Evidence for specific high density lipoprotein-binding sites on isolated rat intestinal mucosal cells. J Lipid Res 24:253–264

    PubMed  CAS  Google Scholar 

  • Tall AR (1986) Plasma lipid transfer proteins. J Lipid Res 27:361–367

    PubMed  CAS  Google Scholar 

  • Theret N, Delbart C, Aguie G, Fruchart JC, Vassaux G, Ailhaud G (1990) Cholesterol efflux from adipose cells is coupled to diacylglycerol production and protein kinase C activation. Biochem Biophys Res Commun 173:1361–1368

    Article  PubMed  CAS  Google Scholar 

  • Utermann G (1989) The mysteries of lipoprotein(a). Science 246:904–910

    Article  PubMed  CAS  Google Scholar 

  • Utermann G, Weber W (1983) Protein composition of Lp(a) lipoprotein from human plasma. FEBS Lett 154:357–361

    Article  PubMed  CAS  Google Scholar 

  • Utermann G, Vogelberg KH, Steinmetz A, Schoenborn W, Pruin N, Jaeschke M, Hees M, Canzler H (1979) Polymorphism of apolipoprotein E: II. Genetics of hyperlipoproteinemia type III. Clin Genet 15:37–62

    Article  PubMed  CAS  Google Scholar 

  • Utermann G, Menzel HJ, Kraft HG, Duba HC, Kemmler HG, Seitz C (1987) Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma. J Clin Invest 80:458–465

    Article  PubMed  CAS  Google Scholar 

  • Van der Westhuyzen DR, Fourie AM, Coetzee GA, Gevers W (1990) The LDL receptor. Curr Opin Lipidol 1:128–135

    Article  Google Scholar 

  • Van Lenten BJ, Fogelman AM (1990) Processing of lipoproteins in human monocyte-macrophages. J Lipid Res 31:1455–1466

    PubMed  Google Scholar 

  • Vega GL, Denke MA, Grundy SM (1991) Metabolic basis of primary hypercholesterolemia. Circulation 84:118–128

    PubMed  CAS  Google Scholar 

  • Wetterau JR, Aggerbeck LP, Bouma ME, Eisenberg C, Munck A, Hermier M, Schmitz J, Gay G, Rader DJ, Gregg RE (1992) Absence of microsomal tri-glyceride transfer protein in individuals with abetalipoproteinemia. Science 258: 999–1001

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto T, Davis CG, Brown MS, Schneider WJ, Casey ML, Goldstein JL, Russell DW (1984) The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell 39:27–38

    Article  PubMed  CAS  Google Scholar 

  • Zannis VI, Just PW, Breslow JL (1981) Human apolipoprotein E isoprotein subclasses are genetically determined. Am J Hum Genet 33:11–24

    PubMed  CAS  Google Scholar 

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Brewer, H.B. (1994). Lipoprotein Metabolism. In: Schettler, G., Habenicht, A.J.R. (eds) Principles and Treatment of Lipoprotein Disorders. Handbook of Experimental Pharmacology, vol 109. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78426-2_2

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  • DOI: https://doi.org/10.1007/978-3-642-78426-2_2

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