Fibrates

  • A. Gaw
  • C. J. Packard
  • J. Shepherd
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 109)

Abstract

The fibric acid derivatives, or fibrates, have, until recently, been the most widely used lipid-lowering drugs in clinical practice. In the UK, for the year ending June 1990, the fibrates available at that time (bezafibrate, gemfibrozil and clofibrate) constituted 62% of all prescribed items for hyperlipidaemia. In the same period, bezafibrate was the most widely prescribed lipid-lowering drug (O’Brien 1991). In the US, from 1984–1987, gemfibrozil held first place in the ranking of lipid-lowering drugs in terms of number of prescriptions written and was only overtaken in 1988, after the introduction of lovastatin (Wysowski et al. 1990).

Keywords

Placebo Cholesterol Lipase Stein Myopathy 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • A. Gaw
  • C. J. Packard
  • J. Shepherd

There are no affiliations available

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