Zusammenfassung
Fibroproliferative Prozesse in der Lunge kennzeichnen die im Anschluß an die initialen Entzündungsreaktionen einsetzenden Reparaturmechanismen im ARDS. Bei schweren Verlaufsformen eines ARDS setzt nach einigen Tagen oftmals eine überschießende fibroproliferative Reaktion ein, die gekennzeichnet ist durch obliterierendes Granulationsgewebe und eine enorme Vermehrung von Fibroblasten und Kollagen. Es resultieren eine massive Verschlechterung des Gasaustausches, eine Zunahme von Shunt und Totraumventilation sowie eine verminderte Compliance und eine pulmonale Hypertension. Die exakte Koordination von Migration und Replikation von Epithel-, Mesenchymal- und Endothelzellen sowie die Bildung neuer Matrixproteine sind daher für die Wiederherstellung der Gasaustauschfunktion von entscheidender Bedeutung.
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© 1995 Springer-Verlag Berlin Heidelberg
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Tschaikowsky, K. (1995). Die Fibrosierung der Lunge — eine Folge der (Langzeit)beatmung?. In: Rügheimer, E. (eds) Respiratorische Therapie nach operativen Eingriffen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78399-9_31
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DOI: https://doi.org/10.1007/978-3-642-78399-9_31
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