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Zelluläre und mitochondriale Adaptationsvorgänge bei Hypoxie

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Book cover Respiratorische Therapie nach operativen Eingriffen

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Zusammenfassung

Verglichen mit den Adaptationsvorgängen an Hypoxie, die auf biochemischem und molekularem Gebiet in der Humanphysiologie und klinischen Bioenergetik bekannt sind, weisen die Anpassungen an O2-Mangel im gesamten Tierreich eine erstaunliche Komplexität und Flexibilität metabolischer Stoffwechselprozesse auf (Gnaiger 1993a). Ökologisch ist die Hypoxie besonders in aquatischen Lebensräumen ausgeprägt, was auf die 30- bis 50fach geringere Sättigungskonzentration von Sauerstoff in Wasser im Vergleich mit Luft zurückzuführen ist. Doch auch die Zellen des menschlichen Organismus befinden sich in einem wässrigen Mikromilieu, in dem bei Drosselung der O2-Zufuhr ein schnelles Abfallen des intrazellulären pO2 die Folge ist.

Unterstützung durch den Fonds zur Förderung der wissenschaftlichen Forschung, P7162-BIO, und ein Projekt des BMWF, Österreich. Ich bedanke mich bei Herrn Univ.-Prof. Dr. Raimund Margreiter für sein Interesse und seine Unterstützung.

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Authors
  1. E. Gnaiger
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Editors and Affiliations

  1. Institut für Anaesthesiologie Klinikum, Universität Erlangen-Nürnberg, Krankenhausstr. 12, D-91054, Erlangen, Deutschland

    Erich Rügheimer

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© 1995 Springer-Verlag Berlin Heidelberg

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Gnaiger, E. (1995). Zelluläre und mitochondriale Adaptationsvorgänge bei Hypoxie. In: Rügheimer, E. (eds) Respiratorische Therapie nach operativen Eingriffen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78399-9_1

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  • DOI: https://doi.org/10.1007/978-3-642-78399-9_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-57047-9

  • Online ISBN: 978-3-642-78399-9

  • eBook Packages: Springer Book Archive

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