Zusammenfassung
Im Rückblick können wir heute 2 Eckdaten identifizieren, die entscheidende Durchbrüche für das Verständnis des Renin-Angiotensin-Systems (RAS) erbrachten.
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Literatur
Aceto JF, Baker KM (1990) [Sarl] angiotensin II receptor-mediated stimulation of protein synthesis in chick heart cells. Am J Physiol 258: 806–813
Admiraal PJJ, Derkx FHM, Danser AHJ, Pieterman H, Schalekamp MADH (1990) Metabolism and production of angiotensin I in different vascular beds in subjects with hypertension. Hypertension 15: 44–55
Admiraal PJJ, Derkx FHM, Danser AHJ, Pieterman H, Schalekamp MADH (1990) Intrarenal de novo production of angiotensin I in subjects with renal artery stenosis. Hypertension 16: 555–563
Aguilera G, Schirer A, Baukal A, Catt KJ (1980) Angiotensin II receptors. Properties and regulation in adrenal glomerulosa cells. Circ Res [Supply 1] 46: 118–127
Alderman MH, Madhavan S, Ooi WL, Cohen H, Sealey JE, Laragh JH (1991) Association of the renin- sodium profile with the risk of myocardial infarction in patients with hypertension. N Engl J Med 324: 1098–1104 (1990)
Baker KM, Aceto JF (1990) Angiotensin II stimulation of protein synthesis and cell growth in chick heart cells. Am J Physiol 259: 610–618
Baker KM, Chernin MI, Wixson SK, Aceto JF (1990) Renin-angiotensin system involvement in pressure-overload cardiac hypertrophy in rats. Am J Physiol 259: H324–H332
Berk BC, Vekshtein V, Gordon HM, Tsuda T (1989) Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells. Hypertension 13: 305–314
Brunner HR, Laragh JH, Baer L, Newton MA, Goodwin FT, Krakoff LR, Bard RH, Bühler FR (1972) Essential hypertension: renin and aldosterone, heart attack and stroke. N Engl J Med 286: 441–449
Bumpus FM, Catt KJ, Chiu AT et al. (1991) Nomenclature for angiotensin receptors: A report of the nomenclature committee of the Council for High Blood Pressure Research. Hypertension 17: 720–721
Bunkenberg B, Amelsvoort T van, Rogg H, Wood JM (1992) Receptor-mediated effects of angiotensin II on growth of vascular smooth muscle cells from spontaneously hypertensive rats. Hypertension 20: 746–754
Campagnole-Santos MJC, Diz Dl, Santos RAS, Khosla MC, Brosnihan KB, Ferrario CM (1989) Cardiovascular actions of angiotensin-(1-7) microinjected into the dorsomedial medulla of rats. Am J Physiol 257: H324–H329
Campbell DJ (1985) The site of angiotensin production. J Hypertens 3: 199–207
Campbell DJ (1987) Circulating and tissue angiotensin systems. J Clin Invest 79: 1–6
Campbell DJ, Kladis A (1990) Simultaneous radioimmunoassay of six angiotensin peptides in arterial and venous plasma of man. J Hypertens 8: 165–172
Campbell DJ, Kladis A, Skinner SL, Whitworth JA (1991) Characterization of angiotensin peptides in plasma of anephric man. J Hypertens 9: 265–274
Campbell-Boswell M, Robertson AL (1987) Effects of angiotensin II and vasopressin on human smooth muscle cells in vitro. Exp Mol Pathol 35: 265–276
Catt K, Abbott A (1991) Molecular cloning of angiotensin II receptors may presage further receptor subtypes. Trends Pharmacol Sci 12: 279–281
Chaki S, Inagami T (1992) Identification and characterization of a new angiotensin II receptor subtype in differentiated neuro-2A cells (abstr). Hypertension 20: 397
Crawford DC, Chobanian V, Brecher P (1992) Angiotensin II increases fibronectin expression in rat cardiac fibroblasts in vivo (abstr). Circulation 86: 1–89
De Mello WC, Altieri P (1992) Effect of angiotensin II and enalapril on heart cell coupling (abstr). Circ Res 86: 1–9
Derkx F, Wenting G, Man in’t Veld AJ, Verhoever RP, Schalenkamp MADH (1978) Control of enzymatically inctive renin in man under various pathological conditions: Implications for the interpretation of renin measurements in peripheral and renal venous plasma. Clin Sci Mol Med 54: 529–538
des Senanayake P, Brosnihan B, Kumagi H, Moriguchi A, Martins A, Ganten D, Ferrario CM (1992) Plasma ANG-(l-7) is supressed in hypertensive transgenic rats (abstr). Hypertension 20: 437
Diz DI, Goldfarb DA, Tubbs RR, Ferrario CM, Novick AC (1992) Angiotensin-(1-7) shows selectivity for AT-2 receptors in human renal cortex (abstr). Hypertension 20: 417
Diz DI, Pirro NT (1992) Differential actions of angiotensin II and angiotensin-(1-7) on transmitter release. Hypertension 19: II.41–II. 48
Douglas JG (1986) Regulation of angiotensin receptors. NIPS 1: 67–68
Dubey RK, Roy A, Overbeck HW (1992) Culture of renal arteriolar smooth muscle cells: Mitogenic responses to angiotensin II. Circ Res 71: 1143–1152
Dzau VJ (1989) Multiple pathways of angiotensin production in the blood vessel wall: evidence, possibilities and hypotheses. J Hypertens 7: 933–936
Dzau VJ, Baxter JA, Cantin M et al. (1987) Report of the joint nomenclature and standardization committe of the International Society of Hypertension, the American Heart Association, and the World Health Organization. Hypertension 10: 461–464
Dzau VJ, Pratt RE (1992) Renin angiotensin system. In: Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE (eds) The heart and cardiovascular system. Raven Press, New York, pp 1817–1849
Elton TS, Stephan CC, Taylor GR, Kimball MG, Martin MM, Duran JN, Oparil S (1992) Isolation of two distinct type I angiotensin II receptor genes (abstr). Hypertension 20: 411
Erdds EG (1990) Angiotensin I converting enzyme and the changes in our concepts through the years: Lewis K memorial lecture. Hypertension 16: 363–370
Finckh M, Hellmann W, Ganten D, Furtwangler A, Allgeier J, Boltz M, Holtz J (1991) Enhanced cardiac angiotensinogen gene expression and angiotensin converting enzyme activity in tachypacing-induced heart failure in rats. Basic Res Cardiol 86: 303–316
Foult JM, Tavolaro O, Antony I, Nitenberg A (1988) Direct myocardial and coronary effects of enalaprilat in patients with dilated cardiomyopathy: assessment by a bilateral intracoronary infusion technique. Circulation 77: 337–344
Friedrich SP, Lorell BH, Douglas PS (1992) Intracardiac ACE inhibition improves diastolic distensibility in patients with left ventricular hypertrophy due to aortic stenosis (abstr). Circulation 86: 1–119
Fukui K, Inoue H, Takahashi S, Miyake Y (1989) Biosynthesis of a renin binding protein. Biochem Biophys Res Comm 164: 265–270
Galen FX, Devaux C, Hovot AM (1984) Renin biosynthesis of human tumoral juxtaglomerular cells. J Clin Invest 73: 1144–1155
Gasic S, Kleinbloesem CH, Heinz G, Waldhausl W (1991) Contribution of splanchnic and peripheral vascular tissues to the disposal of angiotensin II and to regional conversion rates or angiotensin I: a pilot study in humans. J Cardiovasc Pharnacol 17: 615–620
Geisterfer AAT, Peach MJ, Owens GK (1988) Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells. Circ Res 62: 749–756
Goldblatt H, Lynch J, Hanzal RF, Summerville WW (1939) Studies on experimental hypertension I: The production of persistent elevation of systolic blood pressure by means of renal ischemia. J Exp Med 59: 347–380
Goodfriend TL (1991) Angiotensins: A family that grows from within. Hypertension 17: 139–140
Goodfriend TL, Peach MJ (1975) Angiotensin III: (des-aspartic acidl)-angiotensin II. Circ Res 36 (Suppl I): 138–148
Guyton AC, Coleman TG, Cowley AW, Scheel KW, Manning RD, Normal RA (1972) Arterial pressure regulation. Am J Med 52: 485–594
Haber E (1976) The role of renin in normal and pathological cardiovascular homeostasis. Circulation 54: 849–861
Hall J (1986) Control of sodium excretion by angiotensin II: intrarenal mechanisms and blood pressure regulation. Am J Physiol 250: R960–R972
Hall JE, Brands MW (1992) The renin-angiotensin-aldosterone systems: Renal mechanisms and circulatory homeostasis. In: Seldin DW, Giebisch G (eds) The kidney: physiology and pathophysiology. Raven Press, New York
Heinrikson RL, Hui J, Zurcher-Nelly H, Poorman RA (1989) A structural model to explain the partial catalytic activity of human prorenin. Am J Hypertens 2: 367–380
Hilgers KF, Mann JFE, Hilgenfeldt U, Ganten D (1991) Vascular production and regulation of angiotensin. Blood Vessels 28: 201–209
Hirakata H, Foud-Tarazi FM, Bumpus FM (1990) Angiotensins and the failing heart: enhanced positive inotropic response to angiotensin in cardiomyopthic hamster heart in the presence of captopril. Circ Res 66: 891–899
Hoit BD, Shao Y, Gabel M, Bauer B, Urata H, Husain A, Walsh RA (1992) Hemodynamic effects of an angiotensin II-forming chymase in conscious baboons with high renin hypertension (abstr). Circulation 86: 1–432
Hollenberg NK, Chenitz WR, Adams DF, Williams GH (1974) Reciprocal influence of salt intake of adrenal glomerulosa and renal vascular responses to angiotensin II in normal man. J Clin Invest 54: 34–42
Holtz J (1992) Bedeutung der Myokardhypertrophie bei Herzinsuffizienz. Z Kardiol 81 [Suppl 4]: 41–48
Holtz J (1993) Pathophysiology of renal failure and the renin-angiotensin-system. In: Grobecker H, Heusch G, Strauer B (eds) Angiotensin and the heart. Steinkopff, Darmstadt/Springer, New York, pp 183–201
Holtz J, Finckh M (1991) Pathophysiologic kardiorenaler Regelmechanismen bei Herzin-suffizienz. Z Kardiol 80 [Suppl 2]: 1–10
Hsueh WA, Baxter JD (1991) Human prorenin. Hypertension 17: 469–479
Hsueh WA, Carlson JE, Dzau V (1983) Characterization of inactive renin from human kidney and plasma: evidence for a renal source of circulating inactive renin. J Clin Invest 71: 506–517
Ichikawa I, Pfeffer JM, Pfeffer MA, Hostetter TH, Brenner B (1984) Role of angiotensin II in the altered renal function of congestive heart failure. Circ Res 55: 669–675
Inagami T, Murakami K (1980) Prorenin. Biomed Res 1: 456–475
Inagami T, Murakami T, Higuchi K, Nakajo S (1991) Role of vascular wall renin: intracellular and extracellular mechanism. Blood Vessels 28: 217–223
Jaiswal N, Diz DI, Chappell MC, Khosla MC Ferrario CM (1992) Stimulation of endothelial cell prosta-glandin production by angiotensin peptides. Hypertension 19:11. 49–11. 55
Jaiswal RK, Tallant EA, Diz DI, Ferrario CM (1992) Alterations in prostaglandin production in SHR smooth muscle cells (abstr). Hypertension 20: 432
Jenne DE, Tschopp J (1991) Angiotensin II-forming heart chymase is a mast-cell-specific enzyme. Biochem J 276: 567–568
Kinoshita A, Urata H, Bumpus FM, Husain A (1991) Multiple determinants for the high substrate specificity of an angiotensin II-forming chymase from the human heart. J Biol Chem 266: 19192–19197
Kirchheim H, Emke H, Persson P (1988) Physiology of the renal baroreceptor mechanism of renin release and its role in congestive heart failure. Am J Cardiol 62: 68E–71E
Kohara K, Brosnihan KB, Chappell MC, Khosla MC, Ferrario CM (1991) Angiotensin-(1-7): A member of circulating angiotensin peptides. Hypertension 17: 131–138
Koibuchi Y, Gibbson GH, Pratt RE (1992) Role of TGF-ßl activation in the cellular growth response to Ang II (abstr). Hypertension 20: 418
Landau C, Jacobs AK, Haudenschild CC (1992) Left ventricular hypertrophy induced by angiotensin II is accompanied by a dose dependent fibrotic response (abstr). Circulation 86: 1–754
Laragh JH (1989) Nephron heterogeneity: clue to the pathogenesis of essential hypertension and effectiveness of angiotensin-converting enzyme-inhibitor treatment. Am J Med 87 [Suppl 6B]: S2 - S14
Laragh JH, Baer L, Brunner HR, Bühler FR, Sealey JE, Vaughan ED (1972) Renin, angiotensin and aldosteron system in pathogenesis and management of hypertensive vascular disease. Am J Med 52: 633–652
Lee WH, Packer M (1986) Prognostic importance of serum sodium concentration and its modification by converting-enzyme inhibition in patients will severe chronic heart failure Circulation 73: 257–267
Lewis JL, Serikawa T, Warnock DG (1992) Chromosomal localization of type 1A and IB angiotensin II receptor in the rat (abstr). Hypertension 20: 411
Lindpaintner K, Lu W, Niedermaier N, Schieffer B, Just H, Ganten D, Drexler H (1993) Selective activation of cardiac angiotensinogen gene expression in post-infarction ventricular remodeling in the rat. J Mol Cell Cardiol 25: 133–143
Liu FY, Cogan MG (1989) Angiotensin II stimulation of hydrogen ion secretion in the rat early proximal convoluted tubule. J Clin Invest 82: 601–607
Liu FY, Cogan MG (1989) Angiotensin II stimulates early proximal bicarbonate absorbtion in the rat by decreasing cyclic adenosine monophosphate. J Clin Invest 84: 83–91
Lombes M, Oblin ME, Gasc JM, Baulieu EE, Farman N, Bonvalet JP (1991) Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor. Circ Res 71: 503–510
Loudon M, Bing RF, Thurston H, Swales JD (1983) Arterial wall uptake of renal renin and blood pressure control. Hypertension 5: 629–634
Lyall F, Morton JJ, Lever AF, Cragoe EJ (1988) Angiotensin II activates Na+-H+ exchange and stimulates growth in vascular smooth muscle cells. J Hypertens 6: 438–441
Lynch KR, Peach MJ (1991) Molecular biology of angiotensinogen. Hypertension 17: 263–269
Millan MA (1989) Novel sites of expression of functional angiotensin II receptors in the late gestation fetus. Science 244: 1340–1342
Mizuno K, Higashimori K, Stone WJ, Shimamoto K, Fukuchi S, Inagami T (1990) Re-evaluation of the plasma renin-angiotensin system in anephric patients. Clin Exp Hypertens [A] 12: 1135–1157
Mizuno K, Tani M, Niimura S et al. (1989) Direct evidence for local generation and release of angiotensin II in human vascular tissue. Biochem Biophys Res Comm 165: 457–463
Morishita R, Gibbson G, Kaneda Y, Ogihara T, Dzau V (1992) Novel gene transfer method for study of vascular renin-angiotensin system ( RAS) (abstr ). Hypertension 20: 441
Mulvany MJ, Aalkajaer C (1990) Structure and function of small arteries. Physiol Rev 70: 921–961
Munoz JM, Braun-Menendez E, Fasciolo JC, Leloir LF (1939) Hypertensin: the substance causing renal hypertension. Nature 144: 980
Murphy TJ, Alexander RW, Griendling KK, Runge MS, Bernstein KE (1991) Isolation of a cDNA endocing the vascular type-1 angiotensin II receptor. Nature 351: 233–236
Naftilan AJ, Pratt RE, Dzau VJ (1989) Induction of platelet-derived growth factor A-chain and c-myc gene expression by angiotensin II in cultured rat vascular smooth muscle cells. J Clin Invest 83: 1419–1424
Nakamaru M, Jackson EK, Inagami T (1986) P-Adrenoceptor-mediated release of angiotensin II from mesenteric arteries. Am J Physiol 250: H144–H148
Nussberger J, Brunner DB, Waeber B, Brunner HR (1985) True versus ipmunoreactive angiotensin II in human plasma. Hypertension 7 [Suppl. I]: 11–17
Nussberger J, Brunner DB, Waeber B, Brunner HR (1986) Specific measurement of angiotensin metabolites and in vitro generated angiotensin II in plasma. Hypertension 8: 476–482
Owens GK, Schwartz SM, McCanna M (1985) Evaluation of medial hypertrophy in resistance vessels of spontaneously hypertensive rats. Hypertension 11: 695–705
Packer M (1987) Why do kidneys release renin in patients with congestive heart failure? A nephrocentric view of converting-enzyme inhibition. Am J Cardiol 60: 179–184
Packer M, Lee WH, Kessler PD (1986) Preservation of glomerular filtration rate in human heart failure by activation of the renin-angiotensin system. Circulation 74: 766–774
Page IH, Helmer OM (1940) A crystalline pressor substance (angiotonin) resulting from the action between renin and renin-activator. J Exp Med 71: 29–42
Paquet J-L, Baudouin-Legros M, Brunelle G, Meyer P (1990) Angiotensin II-induced proliferation of aortic myocytes in spontaneously hypertensive rats. J Hypertens 8: 565–572
Pawlowski-Dahm Corinn, Fink GD (1992) Chronic intravenous infusion of angiotensin (1-7) produces increases in circulating vasopressin but not arterial pressure (abstr). Hypertension 20: 437
Pratt RE, Carleton JE, Richie JP, Heusser C, Dzau VJ (1987) Human renin biosynthesis and secretion in normal and ischemic kidneys. Proc Natl Acad Sci USA 84: 7837–7840
Quinn SJ, Williams GH (1988) Regulation of aldosterone secretion. Annu Rev Physiol 50: 409–426
Richards AM, Wittert GA, Espiner EA, Yandle TG, Ikram H, Frampton C (1992) Effect of inhibition of endopeptidase 24.11 on responses to angiotensin II in human volunteers. Circ Res 71: 1501–1507
Robertson JIS (1986) Circulatory basis for the use of angiotensin converting eniyme inhibitors in hypertension and cardiac failure. J Cardiovasc Pharmacol 8 [Suppl 1]: S2–S8
Rubin SA (1992) Alternative splicing of the angiotensin II receptor message is tissue specific in the cardiovascular system (abstr). Circ Res 86: 1–175
Santos RAS, Brosnihan KB, Jacobsen DW, DiCorleto PE, Ferrario CM (1992) Production of angio-tensin-(1-7) by human vascular endothelium. Hypertension 19:11. 56–11. 61
Sasaki K, Yamano Y, Bardhan S et al. (1991) Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor. Nature 351: 230–233
Sasamura H, Hein L, Krieger JE, Pratt RE, Kobilka BK, Dzau VJ (1992) Molecular evidence for two angiotensin (AT-I) receptor isoforms: Tissue distribution and functional implications (abstr). Hypertension 20: 416
Schiavone MT, Santos RAS, Brosnihan KB, Khosla MC, Ferrario CM (1988) Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1-7) heptapeptide. Proc Natl Acad Sci USA 85: 4095–4098
Schnermann J, Briggs JP (1992) Function of the juxtaglomerular apparatus: control of glomerular hemodynamic and renin secretion In: Seldin DW, Giebisch G (eds) The kidney: physiology and pathophysiology. Raven Press, New York, pp 1249–1290
Schorb W, Booz GW, Dostal DE, Chang KC, Baker KM (1992) Angiotensin II receptor mediated growth of cardiac fibroblasts (abstr). Circulation 86: 189
Schwartz SM, Heimark RL, Majesky MW (1990) Developmental mechanisms underlying pathology of arteries. Physiol Rev 70: 1177–1209
Schwyzer R, Sieber P (1956) New synthesis in the peptide field. Chimia 10: 265
Scott-Burden T, Resink TJ, Hahn A WA, Bühler FR (1991) Angiotensin-induced growth related metabolism is activated in cultured smooth muscle cells from spontaneously hyertensive rats and Wistar- Kyoto rats. Am J Hypertens 4: 183–188
Sealey JE, Atlas SA, Laragh JH (1980) Prorenin and other large molecular weight forms of renin. Endocrinol Rev 1: 365–391
Sealey JE, Blumenfeld JD, Bell GM, Pecker MS, Sommers SC, Laragh JH (1988) On the renal basis for essential hypertension: nephron heterogeneity with discordant renin secretion and sodium excretion causing a hypertensive vasoconstriction-volume relationship. J Hypertens 6: 763–111
Sealey JE, Rubattu S (1989) Prorenin and renin as separate mediators of tissue and circulating systems. Am J Hypertens 2: 358–366
Shinagawa T, Do YS, Baxter JD, Carilli C, Schilling J, Hsueh WA (1990) Identification of an enzyme in human kidney that correctly processes prorenin. Proc Natl Acad Sci USA 87: 1927–1931
Smrka AV, Hepler JR, Brown KO, Sternweis P (1991) Regulation of polyphosphoinositide-specific phospholipase C activity by purified G9. Science 251: 804–807
Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Tregear G, Corvol P (1988) Two putative active centers in human angiotensin I converting enzyme revealed by molecular cloning. Proc Natl Acad Sci USA 85: 9286–9390
Stoll M, Metsärinne KP, Gohlke P, Paul M, Unger T (1992) Proliferation of rat heart capillary endothelial cells is attenuated by angiotensin II (abstr). Hypertension 20: 418
Sudhir K, Wilson E, Chatterjee K, Ives HE (1992) Mechanical stretch potentiates angiotensin II induced proliferation in cultured vascular smooth muscle cells (abstr). Hypertension 20: 417
Summers C, Fregly MJ (1989) Modulation of angiotensin II binding sites in neuronal cultures by mineralocorticoids. Am J Physiol 256: 121–129
Takeuchi K, Murphy TJ, Nakamura Y, Alexander RW (1992) Molecular cloning of the rat vascular At-1 angiotensin II receptor gene (abstr). Hypertension 20: 411
Taylor GM, Carmichael DJS, Peart WS (1986) Active and inactive renin in anephric man: a comparison of molecular weight studies with normal human plasma and the effect of a specific monoclonal anti-renin antibody. J Hypertens 4: 703–712
Taylor SJ, Smith JA, Exton JH (1990) Purification from bovine liver membranes of a guanine nucleotide-dependent activator of phosphoinositide-specific phospholipase C. Immunologic identification as a novel G-protein alpha subunit. J Biol Chem 265: 17150–17156
Tewksbury DA (1990) Angiotensinogen: Biochemistry and molecular biology. Ia: Laragh JH, Brenner BM (eds) Hypertension: Pathobiology, diagnosis and management, vol 1. Raven Press, New York, pp 1197–1216
Tigerstedt R, Bergman PG (1898) Niere und Kreislauf. Scand Arch Physiol 8: 223–271
Timmermans PBMWM, Wong PC, Chiu AT, Herblin WF (1991) Nonpeptide angiotensin II receptor antagonists. Trends Pharmacol Sci 12: 55–62
Tsuda T, Kawahara Y, Ishida Y, Koide M, Shii K, Yokoyama M (1992) Angiotensin II stimulates two myelin basic protein/microtubule-associated protein 2 kinases in cultured vascular smooth muscle cells. Circ Res 71: 620–630
Ullian ME, Hutchison FN, Morinelli TA (1992) Aldosterone potentiation of angiotensin II-stimulated protein synthesis (abstr). Hypertension 20: 418
Ullian ME, Schelling JR, Linas SL (1992) Aldosterone enhances angiotensin II receptor binding and inositol phosphate responses. Hypertension 20: 67–73
Urata H, Healy B, Stewart RW, Bumpus FM, Husain A (1990) Angiotensin II-forming pathways in normal and failing hearts. Circ Res 66: 883–890
Urata H, Kinoshita A, Misono KS, Bumpus FM, Husain A (1990) Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. J Biol Chem 265: 22348–22357
Urata H, Kinoshita A, Perez DM, Misono KS, Bumpus FM, Graham RM, Husain A (1991) Cloning of the gene and cDNA for human heart chymase. J Biol Chem 266: 17173–17179
Walker E, Patton CM (1992) Novel vascular angiotensin receptor subtypes and signal pathway in fowl (abstr). Hypertension 20: 435
Wang PH, Do YS, Macaulay L, Shinagawa T, Anderson PW, Baxter JD, Hsueh WA (1991) Identification of renal cathepsin B as a human prorenin Processing enzyme. J Biol Chem 266: 12633–12638
Webb DJ, Cumming AMM et al. (1984) Changes in active and inactive renin and in angiotensin II across the kidney in essential hypertension and renal artery stenosis. J Hypertens 2: 605–614
Wilkes BM, Mento PF, Pearl AR et al. (1991) Plasma angiotensins in anephric humans: evidence for an extrarenal angiotensin system. J Cardio vase Pharmacol 17: 419–423
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Holtz, J. (1996). Renin-Angiotensin-System (RAS). In: Dominiak, P., Bönner, G. (eds) ACE-Hemmer in Klinik und Praxis. Aktuelle Therapieprinzipien in Kardiologie und Angiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78376-0_1
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