Spasticity pp 355-357 | Cite as

Discussion Summary

  • E. Pierrot-Deseilligny
Conference paper


During the discussion of these papers, a major point was raised by Hans Hultborn and discussed by many participants: to what extent does presynaptic inhibition of la fibers and homosynaptic depression participate in vibratory inhibition, and what is the relative contribution of these two mechanisms in the exaggeration of the stretch reflex characterizing spasticity?


Amyotrophic Lateral Sclerosis Presynaptic Inhibition Primary Afferent Depolarization Discussion Summary Post Activation Depression 
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  1. Barnes CD, Pompeiano O (1970) Presynaptic and postsynaptic effects in the monosynaptic pathway to extensor motoneurones following vibrations of synergic muscles. Arch Ital Biol 108:259–294PubMedGoogle Scholar
  2. Burke D, Hagbarth KE, Lofstedt L, Wallin BG (1976) The response of human muscle spindle endings to vibration of non-contracting muscles. J Physiol (Lond) 261:673–693Google Scholar
  3. Crone C, Nielsen J (1989) Methodological implications of the post activation depression of the soleus H-reflex in man. Exp Brain Res 78:28–32PubMedCrossRefGoogle Scholar
  4. Curtis DR, Eccles JC (1960) Synaptic action during and after repetitive stimulation. J Physiol 150:374–398PubMedGoogle Scholar
  5. Dail P, Lance JW, Neilson PD (1966) Differential effects of tonic and phasic reflex mechanisms produced by vibration of muscles in man. J Neurol Neurosurg Psychiatry 29:1–11CrossRefGoogle Scholar
  6. Delwaide PJ (1971) Etude expérimentale de l’hyperréflexie tendineuse en clinique neurologique. Arscia, BrusselsGoogle Scholar
  7. Delwaide PJ (1973) Human monosynaptic reflexes and presynaptic inhibition. An interpretation of spastic hyperreflexia. In: Desmedt JE (ed) New developments in electromyography and clinical neurophysiology, vol 3. Karger, Basel, pp 508–522Google Scholar
  8. Eccles JC, Rail W (1951) Effects induced in a monosynaptic reflex path by its activation. J Neurophysiol 14:353–376PubMedGoogle Scholar
  9. Gillies JD, Lance JW, Neilson PD, Tassinari CA (1969) Presynaptic inhibition of the monosynaptic reflex by vibration. J Physiol 205:329–339PubMedGoogle Scholar
  10. Hagbarth KE, Eklund G (1966) Motor effects of vibratory muscle stimuli in man. In: Granit R (ed) Muscular afferents and motor control. Almqvist and Wiksell, Stockholm, pp 177–186Google Scholar
  11. Hultborn H, Meunier S, Morin C, Pierrot-Deseilligny E (1987) Assessing changes in presynaptic inhibition of la fibres: a study in man and the cat. J Physiol (Lond) 389:729–756Google Scholar
  12. Katz R, Morin C, Pierrot-Deseilligny E, Hibino R (1977) Conditioning of H-reflex by a preceding subthreshold tendon reflex stimulus. J Neurol Neurosurg Psychiatry 40:575–580PubMedCrossRefGoogle Scholar
  13. Lloyd DP, Wilson VJ (1957) Reflex depression in rythmically actived monosynaptic reflex pathways. J Gen Physiol 40:409–426PubMedCrossRefGoogle Scholar
  14. Morin C, Pierrot-Deseilligny E (1988) Mécanisme spinal de l’action antispastique de la TRH chez les malades atteints de sclérose latérale amyotrophique. Rev Neurol (Paris) 144:701–703Google Scholar
  15. Schmidt RF (1971) Presynaptic inhibition in the vertebrate central nervous system. Ergeb Physiol 63:20–101PubMedCrossRefGoogle Scholar
  16. Stratten WP, Barnes CD (1971) Diazepam and presynaptic inhibition. Neuropharmacology 10:685–696PubMedCrossRefGoogle Scholar
  17. Taborikova H, Sax DS (1969) Conditioning H-reflex by a preceding subthreshold H-reflex stimulus. Brain 92:203–212PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • E. Pierrot-Deseilligny
    • 1
  1. 1.RééducationHôpital de la SalpètriéreParis Cedex 13France

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