Advertisement

Fibrinolysestörungen — analytische Voraussetzungen und klinische Bedeutung

  • C. Kluft
Conference paper

Zusammenfassung

Gerinnung und Fibrinolyse sind 2 Prozesse, die die Formung und Auflösung des Fibrins bestimmen. Theoretischerweise können sowohl Störungen der Gerinnung als auch der Fibrinolyse (oder eine Dysbalance beider Prozesse, die durch relativ kleine, aber einander verstärkende Änderungen entsteht) zu klinischen Konsequenzen wie Blutungen, gestörter Gewebereparatur und Thrombosen führen, die zusammenhängen mit insuffizienter oder übermäßiger Anwesenheit des Fibrins.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Aoki N (1987) Hereditary abnormalities of the fibrinolytic system. In: Francis JL (ed) Fibrinogen, fibrin stabilization and fibrinolysis. Ellis Horwood, Chicester, pp 264–266Google Scholar
  2. 2.
    Dieval J, Gross S, Nguyen G, Kruithof EKO, Delobel J (1989) Bleeding diathesis related to a deficiency in plasminogen activator inhibitor 1 in a young patients. Thromb Haemostas 62:474Google Scholar
  3. 3.
    Schleef RR, Higgins DL, Pillemer E, Levitt LJ (1989) Bleeding diathesis due to decreased functional activity of type 1 plasminogen activator inhibitor. J Clin Invest 83:1747–1752PubMedCrossRefGoogle Scholar
  4. 4.
    Booth NA, Bennett B, Wijngaards G, Grieve JHK (1983) A new life-long hemorrhagic disorder due to excess plasminogen activator. Blood 61:267–275PubMedGoogle Scholar
  5. 5.
    Aznar J, Estelles A, Vila V, Reganon E, Espana F, Villa P (1984) Inherited fibrinolytic disorder due to an enhanced plasminogen activator level. Thromb Haemostas 52:196–200Google Scholar
  6. 6.
    Dolan G, Preston FE (1988) Familial plasminogen deficiency and thromboembolism. Fibrinolysis 2 (Suppl 2): 26–34CrossRefGoogle Scholar
  7. 7.
    Lijnen HR, Collen D (1989) Congenital and acquired deficiencies of components of the fibrinolytic system and their relation to bleeding and thrombosis. Fibrinolysis 3:67–77CrossRefGoogle Scholar
  8. 8.
    Samama M, Conard J, Soria J (1988) Congenital dysfibrinogenemia and thrombosis. Fibrinolysis 2 (Suppl 2): 18–23CrossRefGoogle Scholar
  9. 9.
    Koopman JL (1992) Structure-function analysis of hereditary variant human fibrinogens. Thesis, Leiden University, NetherlandsGoogle Scholar
  10. 10.
    Engesser L, Kluft C, Briet E, Brommer EJP (1987) Familial elevation of plasma histidine-rich glycoprotein in a family with thrombophilia. Br J Haematol 67:355–358PubMedCrossRefGoogle Scholar
  11. 11.
    Engesser L, Kluft C, Juhan-Vague I, Briët E, Brommer EJP (1988) Plasma histidine-rich glycoprotein and thrombophilia. Fibrinolysis 2 (Suppl 2): 43–46CrossRefGoogle Scholar
  12. 12.
    Nilsson EM, Ljungner H, Tengborn L (1985) Two different mechanisms in patients with venous thrombosis and defective fibrinolysis: low concentration of plasminogen activator or increased concentration of plasminogen activator inhibitor. Br Med J 290:1453–1455CrossRefGoogle Scholar
  13. 13.
    Juhan-Vague I, Valadier J, Alessi MC, Aillaud MF, Ansaldi J, Philip-Joet C, Holvoet P, Serradimigni A, Collen D (1987) Deficient t-PA release and elevated PA inhibitor levels in patients with spontaneous or recurrent deep vein thrombosis. Thromb Haemostas 57:67–72Google Scholar
  14. 14.
    Kluft C (1990) Congenital deficiencies in fibrinolysis. Med Razgl 29 (Suppl 1):29–41Google Scholar
  15. 15.
    Levi M, Lensing AWA, Butler HR, Prandoni P, Dooijewaard G, Cuppini S, ten Cate JW (1991) Deep-vein thrombosis and fibrinolysis: defective urokinase type plasminogen activator release. Thromb Haemostas 66:426–429Google Scholar
  16. 16.
    Jansson H, Nilsson TK, Olofsson BO (1991) Tissue plasminogen activator and other risk factors as predictors of cardiovascular events in patients with severe angina pectoris. Eur Heart J 12: 157–161PubMedGoogle Scholar
  17. 17.
    Hamsten A, De Faire V, Walldius G, Dahlen G, Szamosi A, Landon C, Blombäck M, Wiman B (1987) Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction. Lancet II:3–9CrossRefGoogle Scholar
  18. 18.
    Gram J, Jespersen J (1987) A selective depression of tissue plasminogen activator (t-PA) activity in euglobulins characterises a risk group among young survivors of acute myocardial infarction. Thromb Haemostas 52:137–139Google Scholar
  19. 19.
    Jespersen J, Munkvad S, Pedersen OD, Gram J, Kluft C (1992) Evidence for a role of factor XII-dependent fibrinolysis in cardiovascular diseases. In: Brakman P, Kluft C (eds) Plasminogen activation in fibrinolysis, in tissue remodeling, and in development. Ann NY Acad Sci 667:454–456Google Scholar
  20. 20.
    Kluft C (1990) Disorders of the haemostatic system and the risk of development of thrombotic and cardio-vascular diseases: Limitations of laboratory diagnosis. Am J Obstet Gynecol 163:305–312PubMedGoogle Scholar
  21. 21.
    Emeis JJ (1992) Regulation of the acute release of tissue-type plasminogen activator from the endothelium by coagulation activation products. In: Brakman P, Kluft C (eds) Plasminogen activation in fibrinolysis, in tissue remodeling, and in development. Ann NY Acad Sci 667:249–258Google Scholar
  22. 22.
    Levi M, Ten Cate JW, Dooijewaard G, Sturk A, Brommer EJP, Agnelli G (1989) DDAVP induces systemic release of urokinase-type plasminogen activator. Thromb Haemostas 62: 686–689Google Scholar
  23. 23.
    Potter van Loon BJ, Rijken DC, Brommer EJP, van der Maas APC (1992) The amount of plasminogen, tissue-type plasminogen activator and plasminogen activator inhibitor type 1 in human thrombi and the relation to ex-vivo lysibility. Thromb Haemostas 67:101–105Google Scholar
  24. 24.
    Kluft C, Dooijewaard G, Emeis JJ (1987) Role of the contact system in fibrinolysis. Semin Thromb Hemost 13:50–68PubMedCrossRefGoogle Scholar
  25. 25.
    Binnema DJ, Dooijewaard G, van Iersel JJL, Turion PNC, Kluft C (1990) The contact-system dependent plasminogen activator from human plasma: Identification and characterization. Thromb Haemostas 64:390–397Google Scholar
  26. 26.
    Kluft C (1978) Determination of prekallikrein in human plasma: optimal conditions for activating prekallikrein. J Lab Clin Med 91:83–95PubMedGoogle Scholar
  27. 27.
    Munkvad S, Jespersen J, Gram J, Kluft C (1991) Depression of Factor XII-dependent fibrinolytic activity characterizes patients with early myocardial reinfarction after recombinant tissue-type plasminogen activator therapy. J Am Coll Cardiol 18:454–458PubMedCrossRefGoogle Scholar
  28. 28.
    Kluft C, Munkvad S, Gram J, Jespersen J (1992) Variable depletion of endogenous factor XII-dependent fibrinolytic activity following thrombolytic therapy of myocardial infarction and its relation to reinfarction. Agents & Actions 38 II:299–304Google Scholar
  29. 29.
    Gaussem P, Levy C, Saint-Jean O, Dooijewaard G, Angles-Cano E (1992) Plasma levels of single-chain urokinase in the elderly. Fibrinolysis 6 (Suppl 3): 66–67CrossRefGoogle Scholar
  30. 30.
    Munkvad S, Dooijewaard G, Jespersen J, Kluft C (1990) A depression of the urokinase-related fibrinolytic system in plasma in patients with acute myocardial infarction compared to unstable angina pectoris. Fibrinolysis 4 (Suppl 3): 146 (abstract 376)Google Scholar
  31. 31.
    Dooijewaard G, de Boer A, Turion PN, Cohen AF, Breimer DD, Kluft C (1991) Physical exercise induces enhancement of urokinase-type plasminogen activator (u-PA) levels in plasma. Thromb Haemostas 65:82–86Google Scholar
  32. 32.
    Brommer EJP, Wall Bake W van de, Dooijewaard G (1991) Non-responsiveness of t-PA and u-PA to DDAVP in glomerulonephritis. Thromb Haemostas 65:975Google Scholar
  33. 33.
    Kluft C (1990) Endothelium as a source of tissue-type plasminogen activator (t-PA) for fibrinolysis. In: Warren JB (ed) The endothelium: An introduction to current research. Wiley-Liss, New York, pp129–139Google Scholar
  34. 34.
    Ranby M, Sundell IB, Nilsson TK (1989) Blood collection in strong acid citrate anticoagulant used in a study of dietary influence on basal t-PA activity. Thromb Haemostas 62: 917–922Google Scholar
  35. 35.
    Wejkum I, Rosen S, Sorskog L, Brandt B, Chmielewska J (1990) Blood sampling and determination of tissue plasminogen activator activity with COA-SETR t-PA. Fibrinolysis, 4 (Suppl 2): 152–154CrossRefGoogle Scholar
  36. 36.
    Meijer P, Boon R, Jie AFH, Rosen S, Kluft C (1992) Bioimmunoassay for tissue-type plasminogen activator (t-PA) in human plasma: evaluation of blood sampling and handüng procedures and comparison with other t-PA activity methods. Fibrinolysis 6, (Suppl 3):97–99CrossRefGoogle Scholar
  37. 37.
    Dooyewaard G, Boheemen PA van, Binnema DJ, Kluft C (1992) The rationale of prevention of thrombosis by enhancing blood levels of single-chain urokinase-type plasminogen activator (scuPA). In: Brakman P, Kluft C (eds) Plasminogen activation in fibrinolysis, in tissue remodeling, and in development. Ann NY Acad Sci 667:278–280Google Scholar
  38. 38.
    Kluft C, Verheijen JH (1990) Leiden fibrinolysis working party: Blood collection and handling procedures for assessment of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1). Fibrinolysis 4 (Suppl 2): 155–161CrossRefGoogle Scholar
  39. 39.
    Brommer EJP, Gevers Leuven JA, Barrett-Bergshoeff MM, Schouten JA (1982) Response of fibrinolytic activity and factor VIII-related antigen to stimulation with Desmopressin in hyperlipoproteïnemia. J Lab Clin Med 100:105–114PubMedGoogle Scholar
  40. 40.
    Kluft C, Jie AFH, Kooistra T, Knijff P de, Geus EJC de, Schaafsma G, Veenstra J (1992) Alcohol and fibrinolysis. In: Veenstra J, Heij DG van de (eds) Alcohol and cardiovascular disease. Wageningen, Pudoc, pp45–63Google Scholar
  41. 41.
    Keber D (1988) Mechanism of tissue plasminogen activator release during venous occlusion. Fibrinolysis 2 (Suppl 2):96–103CrossRefGoogle Scholar
  42. 42.
    Cohen AF, Burggraaf K, De Boer A, Kluft C (1992) Clearance of plasminogen activators-A major determinant of plasma concentration. Therapeutic and diagnostic implications. In: Brakman P, Kluft C (eds) Plasminogen activation in fibrinolysis, in tissue remodeling, and in development. Ann NY Acad Sci 667:443–449Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • C. Kluft

There are no affiliations available

Personalised recommendations