Therapy of Acute Myelogenous Leukemia in Childhood — Results of the Multicenter Trial AML II/87 in East Germany

  • J. Hermanni
  • D. Fuchs
  • R. Häfer
  • A. Müller
  • H. Palme
  • J. Prager
  • W. Dörffel
  • M. Domula
  • G. Eggers
  • P. Exadaktylos
  • E. Hilgenfeld
  • I. Krause
  • W. Kunert
  • U. Mittler
  • D. Möbius
  • H. Reddemann
  • V. Scharfe
  • E. Siegert
  • G. Weinmann
  • F. Zintl
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 36)

Abstract

The prognosis of childhood AML has been improved within the last decade by more intensive combination chemotherapy, better supportive care and, perhaps, by bone marrow transplantation.

Keywords

Leukemia Methotrexate Prednisolone Peritonitis Cytosine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1976) Proposals for the classification of the acute leukaemias. Brit J Haematol 33: 451–458CrossRefGoogle Scholar
  2. 2.
    Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1985) Proposed revised criteria for the classification of acute myeloid leukaemia. Ann Int Med 103: 620–625Google Scholar
  3. 3.
    Bertino JR, Sawicki WL, Cashmore AR, Cadman EC, Skeel RT (1977) Natural resistance to methotrexate in human acute nonlymphocytic leukemia. Cancer Treat Rep 61: 667–673PubMedGoogle Scholar
  4. 4.
    Ciaiolo C, Ferrero D, Pugliese A, Biglino A, Marletto G, Tonello M. Colzani G, Marietti G (1988) Enhancement of methotrexate cytotoxicity by modulation of proliferative activity in normal and neoplastic T lymphocytes and in a myeloid leukaemia cell line. Tumori 74: 537–542PubMedGoogle Scholar
  5. 5.
    Creutzig U, Ritter J, Langermann H-J, Riehm H, Henze G, Niethammer D, Jürgens H, Stollmann B, Lasson U, Kabisch H, Wahlen W, Lömer H, Schellong G (1983) Akute myeloische Leukämie bei Kindem: Ergebnisse der kooperativen Therapiestudie BFM-78 nach 3 3/4 Jahren. Klin Pädiat 195: 152–160CrossRefGoogle Scholar
  6. 6.
    Creutzig U, Ritter J, Schellong G for the AML-BFM-Study Group (1990) Identification of two risk groups in childhood acute myelogenous leukaemia after therapy intensification in study AML-BFM-83 as compared with study AMLBFM- 78. Blood 75: 1832–1940Google Scholar
  7. 7.
    Creutzig U, Ritter J, Schellong G (Eds.) (1990) Acute myelogenuus leukaemia in childhood. Springer-Verlag, Berlin-Heidelberg-New York London-Paris-Tokio-Hong Kong-BárcelonaGoogle Scholar
  8. 8.
    Hermann J, Fuchs D, Prager J, Palme H, Müller A, Füller J, Vogelsang H, Zintl F (1992) Ergebnisse der allogenen und autologen Knochenmarktransplantation bei Kindem mit akuter myeloischer Leukämie. Kinderärztl Praxis 60: 35–39Google Scholar
  9. 9.
    Hermann J, Plenert W, Zintl F, Fuchs D, Malke H, Dörffel W, Eggers G, Exadaktylos P, Hilgenfeld E, Kotte W, Krause I, Kunert W, Mahal KH, Mittler U, Potel S, Reddemann H, Rönisch PS, Weinmann G (1987) Improved treatment results in childhood acute nonlymphoblastic leukemia with the BFM-AML protocol 78 in a multicenter study in the GDR. Haematology and Blood Transfusion Vol. 30, Acute leukemias, Ed. by Büchner, Schellong, Hiddemann, UrbanitzRitter, Springer Verlag Berlin HeidelbergGoogle Scholar
  10. 10.
    Hermann J, Zintl F, Malke H, Reimann M, Dorffel W, Dömula M, Eggers G, Exadaktylos P, Hilgenfeld E, Kotte W, Krause I, Kunert W, Mittler U, Möbius D, Reddeman H, Rönisch P, Weinmann G (1988) Die akuten nichtlymphatischen Leukämien im Kindesalter-Ergebnisse der ersten prospektiven multizentrischen Therapiestudie AML 1/82 der DDR. Kinderärztl Praxis 56: 477–486Google Scholar
  11. 11.
    Kaplan EL, Meier P (1958) Non-parametric estimation from incomplete observations. Am Statist Assoc 53: 457–481CrossRefGoogle Scholar
  12. 12.
    Zintl F, Hermann J, Fuchs D, Prager J, Müller A, Reiners B, Burger E, Götz I, Kob D (1989) Status of allogeneic bone marrow transplantation in childhood in the GDR. Fol Haematol 116: 389–396Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • J. Hermanni
    • 1
  • D. Fuchs
  • R. Häfer
  • A. Müller
  • H. Palme
  • J. Prager
  • W. Dörffel
  • M. Domula
  • G. Eggers
  • P. Exadaktylos
  • E. Hilgenfeld
  • I. Krause
  • W. Kunert
  • U. Mittler
  • D. Möbius
  • H. Reddemann
  • V. Scharfe
  • E. Siegert
  • G. Weinmann
  • F. Zintl
  1. 1.Universitäts-Kinderklinik JenaJenaGermany

Personalised recommendations