High-Dose Cytosine Arabinoside in the Treatment of Acute Lymphoblastic Leukaemia

  • A. Z. S. Rohatiner
  • R. Bassan
  • R. Battista
  • J. E. Kingston
  • J. Amess
  • M. Carter
  • A. M. Oza
  • J. S. Whelan
  • E. Dini
  • T. Barbui
  • T. A. Lister
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 36)

Abstract

“High-dose” cytosine arabinoside (HD-ara-C) was introduced into the management of acute lymphoblastic leukaemia (ALL) in adults at St. Bartholomew’s Hospital (SBH), London, Ospedali Riuniti, Bergamo and Ospedale San Bortolo, Vicenza in 1981. Prior to this time, a strategy of remission induction and consolidation with adriamycin, vincristine prednisolone and L-asparaginase (OPAL) [1,2], with subsequent dose escalation and addition of cyclophosphamide (HEAV’D) [2,3], followed by cranial irradiation and maintenance chemotherapy, left much room for improvement. Analysis of the prognostic significance of pretreatment variables made it possible to assign patients to either “low-risk” (cALLa positive, blast count < 10 × 109/I) or “high-risk” (the rest) categories [2].

Keywords

toxIcity Lymphoma Leukemia Oncol Cyclophosphamide 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • A. Z. S. Rohatiner
    • 1
  • R. Bassan
    • 1
  • R. Battista
    • 1
  • J. E. Kingston
    • 1
  • J. Amess
    • 1
  • M. Carter
    • 1
  • A. M. Oza
    • 1
  • J. S. Whelan
    • 1
  • E. Dini
    • 1
  • T. Barbui
    • 1
  • T. A. Lister
    • 1
  1. 1.ICRF Dept of Medical OncologySt Bartholomew’s HospitalLondonUK

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