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FAB Morphology and Prognosis in Childhood Acute Lymphoblastic Leukemia (ALL)

  • T. Urasiński
  • J. Peregud-Pogorzelski
  • B. Meźyk
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 36)

Abstract

Despite the contribution of new diagnostic tools (immunology, genetics) most leukemias are still diagnosed on basis of examination of blood and bone marrow films. Several attempts had been made to classify leukemias on basis of morphology but none of them was satisfactory enough in respect to its accuracy and reproducibility. Moreover, none of them had a prognostic significance [1]. In 1976 the French-American-British (FAB) morphological classification of acute leukemias has been proposed and soon after it has gained the common acceptance of haematologists [2,3]. However, opinions of its prognostic significance in childhood acute lymphoblastic leukemia (ALL) are still confusing.

Keywords

Acute Lymphoblastic Leukemia Prognostic Significance Acute Leukemia Childhood Acute Lymphoblastic Leukemia Pediatric Oncology Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Nelson DA (1976) Morphological diagnosis of acute leukemias. Sem Oncol 3: 201–208Google Scholar
  2. 2.
    Bennet JM et al. (1976) Proposals for the classification of the acute leukemias. Br J Haemat 33: 451–458CrossRefGoogle Scholar
  3. 3.
    Chessells JM (1982) Acute lymphoblastic leukemia. Sem Haemat 19: 155–171Google Scholar
  4. 4.
    Bennet JM et al. (1981) The French-AmericanBritish (FAB) Co-operative Group. The morphological classification of acute lymphoblastic leukemia: concordance among observers and clinical correlations. Br J Haemat 47: 553–561CrossRefGoogle Scholar
  5. 5.
    Riehm H et al. (1987) Therapy results in five ALL-BFM studies since 1970: implications of risk factors for prognosis. Haemat Bluttransf 30: 139–147CrossRefGoogle Scholar
  6. 6.
    Urasińlski T et al. (1991) Modified REZ BFM 79 protocol in relapsed childhood ALL. Haemat Blood Transf (in press)Google Scholar
  7. 7.
    Ludwig WD et al. (1991) Incidence and prognostic significance of immunophenotypic subgroups in ALL: experience of the ALL-BFM study 86. (abstract) International Workshop: Recent Advances in Tumour Cell Biology of Acute Leukemias. Berlin, June 1991.Google Scholar
  8. 8.
    Keleti J et al. (1978) Morphological classification of acute leukemias. Br J Haemat 40: 501–506CrossRefGoogle Scholar
  9. 9.
    Vecchi V et al. (1981) Prognostic significance of Iymphoblasts morphology in acute lymphoblastic leukemia (ALL) in childhood. Br J Haemat 45: 178–181CrossRefGoogle Scholar
  10. 10.
    Wagner VM et al. (1979) Correlation of FAB morphologic criteria and prognosis in acute lymphocytic leukemia of childhood. Am J Ped Haemat Oncol 1: 103–106Google Scholar
  11. 11.
    Miller DR et al. (1981) Prognostic importance of morphology (FAB classification) in childhood acute lymphoblastic leukemia. Br J Haemat 48: 199–206Google Scholar
  12. 12.
    Van Eys et al. (1986) The French-AmericanBritish (FAB) classification of leukemia. The Pediatric Oncology Group experience with lymphocytic leukemia. Cancer 57: 1046–1051PubMedCrossRefGoogle Scholar
  13. 13.
    Viana MB et al. (1980) Subclassification of acute lymphoblastic leukemia in children: analysis of the reproducibility of morphological criteria and prognostic implications. Br J Haemat 44: 383–388CrossRefGoogle Scholar
  14. 14.
    Childs CC et al. (1986) The morphologic classification of acute lymphoblastic leukemia in childhood. Am J Clin Pathol 86: 503–506PubMedGoogle Scholar
  15. 15.
    Browman GP et al. (1986) The contribution of cytochemistry and immunophenotyping to the reproducibility of the FAB classification in acute leukemia. Blood 68: 900–905PubMedGoogle Scholar
  16. 16.
    Reid MM et al. (1982) Failure of FAB classification to predict relapse-free survival in acute leukemia. Lancet 11: 153–154CrossRefGoogle Scholar
  17. 17.
    Davey Fr et al. (1983) Prognostic significance of the revised French-American-British classification for acute lymphocytic leukemia. Clin Lab Haemat 3: 343–351Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • T. Urasiński
    • 1
  • J. Peregud-Pogorzelski
    • 1
  • B. Meźyk
    • 1
  1. 1.Pediatric InstitutePomeranian Medical AcademySzczecinPoland

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