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Vertebral Compression Fractures in the Course of Acute Lymphoblastic Leukemia in Children

  • M. Ochocka
  • M. Matysiak
  • J. Armata
  • G. Dobaczewski
  • G. Gawrońska
  • D. Michaleswska
  • D. Sońta-Jakimczyk
  • G. Ŝladkowska
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 36)

Abstract

Leukemic infiltrates of long bones manifested by pain and radiologic changes are common and well known symptoms of acute lymphoblastic leukemia (ALL) in children [1, 3, 5]. Leukemic vertebral involvement causing compression fractures is a rare symptom of this disease. If present it causes pain, inability to walk and besides ALL treatment it often warrants orthopedic intervention [21]. It would seem that the vertebral involvement would be a bad prognostic factor, meanwhile the literature on vertebral compressions demonstrates, that most of the patients go into complete hematologic and bone remissions [4, 21].

Keywords

Compression Fracture Rheumatic Fever Vertebral Compression Fracture Childhood Leukemia Childhood Acute Lymphoblastic Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Aur RJA, Westbrock W, Rigs W (1972) Childhood acute lymphocytic leukemia. Initial radiological bone involvement and prognosis. Am J Dis Child 124: 653–654PubMedGoogle Scholar
  2. 2.
    Blatt J, Martini SL, Perchansky L (1984) Characteristic of acute lymphoblastic leukemia in children with osteopenia and vertebral compression fractures. J Pediatr 105: 863–865Google Scholar
  3. 3.
    Clausen N, Gotze H, Pedersen A, Rus-Petersen J, Tjalve E (1983) Skeletal scintigraphy and radiography at onset of acute lymphocytic leukemia in children. Med and Pediat Oncol 11: 291–296CrossRefGoogle Scholar
  4. 4.
    DeCastro LA, Kuhn JP, Fresman AI, Sinks LF, Mindell ER (1977) Complete remodelling of the vertebre in child successfully treated for acute lymphoblastic leukemia. Cancer 40: 398–401CrossRefGoogle Scholar
  5. 5.
    Epstein BD (1957) Vertebral changes in childhood leukemia. Radiology 68: 65–69PubMedGoogle Scholar
  6. 6.
    Gann IM, Gupta S, Palmer MK, Morris-Jones PH (1979) The prognostic significance of radiological and symptomatic bone involvement in childhood acute lymphoblastic leukaemia. Med Pediatr Oncol 6: 51–55CrossRefGoogle Scholar
  7. 7.
    Hilbish TF, Bosse BE, Lusted LB, Daves ML, Thomas LB, Forkner CA (1959) Acute leukemia. Skeletal manifestations in children and adults. Arch Intern Med 104: 741–745PubMedCrossRefGoogle Scholar
  8. 8.
    Hughes RG, Kay HEM (1982) Major bone lesions in acute lymphoblastic leukaemia. Med Pediatr Oncol 10: 67–70PubMedCrossRefGoogle Scholar
  9. 9.
    Kozlowski JB, Campbell JC, Leonidas JC, Stevens M (1987) Unusual radiographic bone abnormalities in leukaemia J Belge Radiol 70: 229–233PubMedGoogle Scholar
  10. 10.
    Madera G, Carnelli V, Ferrari M, Recchia M, Bellini F (1977) Prognostic significance of radiological bone involvement in childhood acute lymphoblastic leukaemia. Arch Dis Childh 52: 530–533CrossRefGoogle Scholar
  11. 11.
    Newman AJ, Melhorn DK (1973) Vertebral compression in childhood leukaemia. Am J Dis Child 125: 863–865PubMedGoogle Scholar
  12. 12.
    Ochocka M (1982) Hematologia kliniczna wieku dziecięcego PZWL, Warszawa (in polish)Google Scholar
  13. 13.
    Pinkel D (1976) Curability of childhood cancer, JAMA 235: 1049–1050PubMedCrossRefGoogle Scholar
  14. 14.
    Pinkel D, Simone J, Hustu HD, Aur RJA (1972) Nine years experience with “total therapy” of childhood acute lymphoblastic leukemia. Pediatrics 50: 246–251PubMedGoogle Scholar
  15. 15.
    Raisz LG, Luben RA, Mundy GR, Dietrich JW, Horton JE, Trummel CL (1975) Effect of osteoclast activating factor from human leukocytes on bone metabolism. J Clin Invest 56: 408–413PubMedCrossRefGoogle Scholar
  16. 16.
    Ramsey NKC, Brown MD, Nesbit ME, Coccia PF, Crivit W, Krutzik S (1979) Autonomous production of parathyroid hormone by lymphoblastic leukemia cells in culture. J Pediatr 94: 623–625CrossRefGoogle Scholar
  17. 17.
    Riberro RC, Ching-Hon Pui, Schell J (1988) Vertebral compression fracture as a presenting 388 feature of acute lymphoblastic leukemia in children. Cancer 61: 589–592CrossRefGoogle Scholar
  18. 18.
    Riehm H (1982) Therapie der akuten Leukemie beim Kind in: Aktuelle Therapie boesartiger Blutkrankheiten, Springer Berlin, Heidelberg, New YorkGoogle Scholar
  19. 19.
    Rogalsky RJ, Black B, Reed MH (1986) Orthopaedic manifestations of leukemia in children. J Bone Joint Surg 68: 494–501PubMedGoogle Scholar
  20. 20.
    Rosenfield NS, McIntosh S (1977) Prospective analysis of bone changes in treated childhood leukemia 123: 413–415, (Radiology)Google Scholar
  21. 21.
    Samuda GM, Cheng MB, Yeung CY (1987) Back pain and vertebral compression: an uncommon presentation of childhood acute lymphoblastic leukemia. J Pediatr Orthop 7: 175–178PubMedCrossRefGoogle Scholar
  22. 22.
    Thomas LB, Forkner CE, Frei E, Besse VE, Stabenau JR (1961) The skeletal lesions of acute leukaemia. Cancer 14: 608–621PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • M. Ochocka
    • 1
  • M. Matysiak
    • 1
  • J. Armata
    • 2
  • G. Dobaczewski
    • 3
  • G. Gawrońska
    • 4
  • D. Michaleswska
    • 5
  • D. Sońta-Jakimczyk
    • 6
  • G. Ŝladkowska
    • 7
  1. 1.Department of Pediatric Hematology-OncologySchool of MedicineWarsawPoland
  2. 2.Department of Pediatric HematologySchool of MedicineKrakówPoland
  3. 3.Department of Pediatric Hematology-OncologySchool of MedicineWrocławPoland
  4. 4.Department of Pediatric Hematology-OncologySchool of MedicineWarsawPoland
  5. 5.Institute of PediatricsSchool of MedicinePoznańPoland
  6. 6.Department of Pediatric OncologySchool of MedicineZabrzePoland
  7. 7.Institute of PediatricsSchool of MedicineLublinPoland

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