Results with Randomized BFM Adopted Studies for ALL Therapy in Childhood in East German Countries

  • F. Zintl
  • H. Malke
  • M. Reimann
  • M. Domula
  • W. Dörffel
  • G. Eggers
  • P. Exadaktylos
  • E. Hilgenfeld
  • W. Kotte
  • I. Krause
  • W. Kunert
  • U. Mittler
  • D. Möbius
  • H. Reddemann
  • G. Weinmann
  • G. Weißbach
  • The former Working Group Pediatric Hematology and Oncology
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 36)

Abstract

After having used different therapy protocols up to 1980 we decided in 1981 to adopt the BFM strategy for treatment of acute lymphoblastic leukemia (ALL) in childhood [1,2]. The aim was to improve outcome for these children by reducing treatment failures caused by inadequate initial reduction of the leukemic cell clone. Published data of the BFM group showed at that time a dramatic improvement in event-free interval by the introduction of a new intensive reinduction therapy element [3,4].

Keywords

Toxicity Leukemia Oncol Prednisone Mitoxantrone 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • F. Zintl
    • 1
  • H. Malke
    • 1
  • M. Reimann
    • 1
  • M. Domula
    • 1
  • W. Dörffel
    • 1
  • G. Eggers
    • 1
  • P. Exadaktylos
    • 1
  • E. Hilgenfeld
    • 1
  • W. Kotte
    • 1
  • I. Krause
    • 1
  • W. Kunert
    • 1
  • U. Mittler
    • 1
  • D. Möbius
    • 1
  • H. Reddemann
    • 1
  • G. Weinmann
    • 1
  • G. Weißbach
    • 1
  • The former Working Group Pediatric Hematology and Oncology
    • 1
  1. 1.Univ.-Kinderklinik “Jussuf Ibrahim” JenaJenaGermany

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