Cytostatic Drug Resistance in Childhood Relapsed Acute Lymphoblastic Leukemia
The treatment of childhood acute lymphoblastic leukemia (ALL) has improved greatly in recent decades. At present, dependent on the risk group, 82% to 100% of the children with ALL will achieve a complete remission (CR) when treated with combination chemotherapy . Overall, about two-thirds will remain in continuous complete remission (CCR). Despite of the current available effective cytostatic drugs, still one-third will get a relapse. Patients suffering from a relapse do have a poor prognosis in which drug resistance of leukemic cells is supposed to playa major role .
KeywordsLeukemia Doxorubicin Glucocorticoid Cytosine Anthracenedione
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- 10.Behrendt H (1991) The significance of relapse in childhood acute lymphoblastic leukemia. PhD thesis, Rodopi, AmsterdamGoogle Scholar
- 12.Livingston RB, Carter SK (1970) Single agents in cancer chemotherapy. IFI/Plenum, New York Washington LondonGoogle Scholar
- 13.Buchanan GR (1990) Diagnosis and management of relapse in acute lymphoblastic leukemia. Hematol/Oncol Clin North Am 4: 971–995Google Scholar