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Cytostatic Drug Resistance in Childhood Relapsed Acute Lymphoblastic Leukemia

  • Conference paper
Acute Leukemias IV

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 36))

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Abstract

The treatment of childhood acute lymphoblastic leukemia (ALL) has improved greatly in recent decades. At present, dependent on the risk group, 82% to 100% of the children with ALL will achieve a complete remission (CR) when treated with combination chemotherapy [1]. Overall, about two-thirds will remain in continuous complete remission (CCR). Despite of the current available effective cytostatic drugs, still one-third will get a relapse. Patients suffering from a relapse do have a poor prognosis in which drug resistance of leukemic cells is supposed to playa major role [2].

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Free University Hospital, Amsterdam, The Netherlands

    E. Klumper, R. Pieters, G. J. L. Kaspers, A. H. Loonen, D. R. Huismans, C. H. van Zantwijk & A. J. P. Veerman

  2. Department of Pediatrics, Sophia’s Children Hospital, Rotterdam, The Netherlands

    K. Hählen

  3. Dutch Childhood Leukemia Study Group, The Hague, The Netherlands

    E. R. van Wering & A. J. P. Veerman

  4. Department of Pediatrics, Free University, Berlin, Germany

    G. Henze

Authors
  1. E. Klumper
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  2. R. Pieters
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  3. G. J. L. Kaspers
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  4. A. H. Loonen
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  5. D. R. Huismans
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  6. C. H. van Zantwijk
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  7. K. Hählen
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  8. E. R. van Wering
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  9. G. Henze
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  10. A. J. P. Veerman
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Germany

    T. Büchner

  2. Department of Pediatrics, University of Münster, Albert-Schweitzer-Strasse 33, 48145, Münster, Germany

    G. Schellong  & J. Ritter  & 

  3. Department of Internal Medicine, University of Göttingen, Robert-Koch-Strasse 40, 37075, Göttingen, Germany

    W. Hiddemann  & B. Wörmann  & 

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© 1994 Springer-Verlag Berlin Heidelberg

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Klumper, E. et al. (1994). Cytostatic Drug Resistance in Childhood Relapsed Acute Lymphoblastic Leukemia. In: Büchner, T., Hiddemann, W., Wörmann, B., Schellong, G., Ritter, J. (eds) Acute Leukemias IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78350-0_51

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  • DOI: https://doi.org/10.1007/978-3-642-78350-0_51

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78352-4

  • Online ISBN: 978-3-642-78350-0

  • eBook Packages: Springer Book Archive

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