Skip to main content
SpringerLink
Log in

Effects on Ara-C Cytotoxicity for AML Colony Forming Cells By Priming With rhGM-CSF and rhIL-3 In Vitro and In Vivo

  • Conference paper
Acute Leukemias IV

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 36))

  • 71 Accesses

Abstract

Resistance of myeloid leukemic blasts to cytosine arabinoside probably is one of the predominant causes of failure to induction chemotherapy in acute myeloid leukemia. Haematopoietic growth factors might be able to increase the cytotoxicity of cycle-specific drugs such as ara-C for myeloid leukemic precursors. Several in vitro studies have been published and clinical trials are under way, including one at this center [1,2]. We investigated the sensitivity of AML blasts to cytosine arabinoside after pretreatment with rhGM-CSF and rhIL-3 in vitro. Samples of patients primed with GM-CSF in vivo were also analysed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bettelheim P, Valent P, Andreef M, Tafuri A, Haimi J, Gorischek C, Muhm M, Sillaber C, Haas O,Vieder L, Maurer D, Schulz G, Speiser W, Geissler K, Kier P, Hinterbereger W, Lechner K (1991) Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor in Combination with Standard Induction Chemotherapy in De Novo Acute Myeloid Leukemia. Blood 77,700

    PubMed  CAS  Google Scholar 

  2. Büchner Th, Hiddemann W, Wörmann B, Rottmann R, Zühlsdorf M, Koenigsmann M, Buntkirchen K, Sander A, Frisch J, Schulz G (1991) Recombinant Human GM-CSF Priming and Long-Term Administration Together with Multiple Course Chemotherapy Vs CT Alone in Newly Diagnosed Acute Myeloid Leukemia. Blood 78, Suppl 1, abstr 641

    Google Scholar 

  3. Cannistra S, Groshek P, Griffin JD (1989) Granulocyte-Makrophage Colony-Stimulating Factor Enhances the Cytotoxic Effects of Cytosine Arabinoside in Acute Myeloblastic Leukemia and in the Myeloid Blast Crisis Phase of Chronic Myeloid Leukemia. Leukemia 3, pp 328–334

    PubMed  CAS  Google Scholar 

  4. Miyauchi J, Kelleher CA, Wang C, Minkin S, McCulloch EA (1989) Growth Factors Influence the Sensitivity of Leukemic Stem Cells to Cytosine Arabinoside in Culture. Blood 73, pp 1272–1278

    PubMed  CAS  Google Scholar 

  5. Koistinen P, Wang C, Curtis JE, McCulloch EA (1991) Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 Protect Leukemic Blast Cells From Ara-C Toxicity. Leukemia 5: 789–795

    PubMed  CAS  Google Scholar 

  6. van der Lely N, de Witte T, Muus P, Raymakers R, Preijers F, Hanen C (1991) Prolonged Exposure to Cytosine Arabinoside in the Presence of Hematopoietic Growth Factors Preferentially Kills Leukemic versus Normal Clonogenic Cells. Exp Hematol 19: 267–272

    Google Scholar 

  7. Lista P, Rossi BM, Resegotti L, Clark SC, Pegoraro L (1990) Different sensitivity of normal and leukemic progenitor cells to ara-C and IL-3 combined treatment. Br J Haematol 76: 21–26

    Article  PubMed  CAS  Google Scholar 

  8. Tafuri A, Andreef M (1990) Kinetic rationale for cytokine-induced recruitment of myeloblastic leukemia followed by cycle-specific chemotherapy in vitro. Leukemia 4, 826–834

    PubMed  CAS  Google Scholar 

  9. Brach M, Klein H, Platzer E, Mertelsmann R, Herrmann F (1990) Effect ofInterieukin 3 on Cyto-sine Arabinoside-mediated Cytotoxicity of Leukemic Myeloblasts. Exp Hematol 18, pp 748–753

    PubMed  CAS  Google Scholar 

  10. Fauser AA, Messner HA (1979) Identification of Megakaryocytes, Macrophages, and Eosinophils in Colonies of Human Bone Marrow 184 Containing Neutrophil Granulocytes and Erythrob lasts. Blood 53, 1023–1027

    PubMed  CAS  Google Scholar 

  11. Chou TC, Talalay P (1984) Quantitative Analysis of Dose-Effect Relationships: The Combined Effects of Multiple Drugs or Enzyme Inhibitors. Adv Enzyme Regul 22, pp 27–55

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medizinische Klinik A, Westfälische Wilhelms Universität Münster, Albert-Schweitzer-Straße 33, 48149, Münster, Germany

    M. Zühlsdorf, S. Weisspfennig, C. Busemann, C. Ameling & T. Büchner

  2. Medizinsche Klinik und Poliklinik, Georg-August-Universität Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany

    B. Wörmann & W. Hiddemann

Authors
  1. M. Zühlsdorf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Weisspfennig
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Busemann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Ameling
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. B. Wörmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. W. Hiddemann
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. T. Büchner
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Germany

    T. Büchner

  2. Department of Pediatrics, University of Münster, Albert-Schweitzer-Strasse 33, 48145, Münster, Germany

    G. Schellong  & J. Ritter  & 

  3. Department of Internal Medicine, University of Göttingen, Robert-Koch-Strasse 40, 37075, Göttingen, Germany

    W. Hiddemann  & B. Wörmann  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Zühlsdorf, M. et al. (1994). Effects on Ara-C Cytotoxicity for AML Colony Forming Cells By Priming With rhGM-CSF and rhIL-3 In Vitro and In Vivo. In: Büchner, T., Hiddemann, W., Wörmann, B., Schellong, G., Ritter, J. (eds) Acute Leukemias IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78350-0_32

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78350-0_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78352-4

  • Online ISBN: 978-3-642-78350-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation