Myeloablative Regimens Containing High Dose Etoposide Followed by Allogeneic or Autologous Bone Marrow Transplantation for Hematologic Malignancies

  • K. G. Blume
  • D. S. Snyder
  • N. J. Chao
  • S. J. Forman
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 36)


Preparatory regimens administered prior to marrow transplantation are intended to eradicate the underlying malignancy and to immunosuppressive the host to allow durable engraftment. The latter is only required for allogeneic marrow graft recipients.


Acute Lymphoblastic Leukemia Chronic Myelogenous Leukemia Autologous Bone Marrow Transplantation Preparatory Regimen Myeloablative Regimen 
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    O’Dwyer PJ, Leyland-Jones B, Alonso MT, Marsoni S, Wittes RE(1985)Etoposide (VP-16-213). Current status of an active anticancer drug. New Engl. J Med 312: 692–700PubMedCrossRefGoogle Scholar
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    Blume KG, Forman SJ, O’Donnell MR, Doroshow JH, Krance RA, Nademanee AP, Snyder DS, Schmidt GM, Fahey JL, Metter GE. Hill LR Findley DO, Sniecinski IJ (1987) Total body irradiation and high-dose etoposide: A new preparatory regimen for bone marrow trasplantation in patients with advanced hematologic malignancies. Blood 69: 10152–1020Google Scholar
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    Horning SJ, Chao NJ, Negrin RS, Hoppe RT, Kwak LW, Long GD, Stallbaum B, O’Connor P, Blume KG (1991) The Stanford experience with high-dose etoposide cytoreductive regimens and autologous bone marrow transplantation in Hodgkin’s disease and non-Hodgkin’s lymphoma: Preliminary data. Ann Oncol 2, Suppl 1: 47–50PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • K. G. Blume
    • 1
  • D. S. Snyder
  • N. J. Chao
  • S. J. Forman
  1. 1.Stanford University Medical CenterStanfordUSA

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