Skip to main content

Clinical Pharmacokinetics of VP-16 — Special Aspects in Children

  • Conference paper
  • 71 Accesses

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 36))

Abstract

The pharmacokinetics of VP-16 by different routes of application has been extensively investigated in the last years.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. D’Incalci M, Farina P, Sessna C, Mangioni C, Conter V, Masera G, Rocchetti, Brambilla Pisoni M, Pidazza E, Beer M, Cavalli F (1982) Pharmacokinetics of VP16–213 given by different administration Methods. Cancer Chemother Pharmacol 7: 141–145

    PubMed  Google Scholar 

  2. Crom WR, Mirro J, Madden T, Petros WP, Belt JK (1989) Targeting plasma concentrations (Cp) of cancer Chemotherapy: Continuous infusion cytarabine (Ara-C) and Etoposide (VP-16) in the treatment of acute nonlymphocytic leukemia (ANLL). European J Clin Pharmacol 36: A66

    Google Scholar 

  3. Evans WE, Petros WP, Reiling M, Crom WR, Madden T, Rodman JH, Sunderland M (1989) Clinical Pharmacology of Cancer Chemotherapy in Children. Pediatric Clinics of North America 36: 1199–1230

    PubMed  CAS  Google Scholar 

  4. Evans WE, Sinkule JA, Crom WR, Dow L, Look AT, Rivera G (1982) Pharmacokinetics of Teniposide (VM26) and Etoposide (VP16–213) in Children with Cancer. Cancer Chemother Pharmacol 7: 147–150

    Article  PubMed  CAS  Google Scholar 

  5. Fleming RA, Miller AA, Stewart CF (1989) Etoposide: An update. Clinical Pharmacy 8: 274–277

    PubMed  CAS  Google Scholar 

  6. Gibaldi M, Perrier D (1982) Pharmacokinetica. Marcel Dekker INC, New York and Basel (Drugs and the Pharmaceutical Sciences Vol 15)

    Google Scholar 

  7. Mirro J, Crom WR, Kalwinsky DK, Santana VM, Baker DK, Belt J (1989) Targeted Plasma Drug Concentration: A New Therapeutic Approach to Relapsed Nonlymphoblastic Leukemia in Children. Haematology and Blood Transfusion 32: 82–87

    PubMed  Google Scholar 

  8. Pflüger KH, Schmidt L, Merkel M, Jungclas H, Havemann K (1987) Drug monitoring of etoposide (VP16–213). Correlation of pharmacokinetic parameters to clinical and biochemical data from patients receiving etoposide. Cancer Chemother Pharmacol 20: 59–66

    Article  PubMed  Google Scholar 

  9. Sinkule JA, Hutson P, Hayes FA, Etcubanas E, Evans W (1984) Pharmacokinetics of Etoposide (VP16) in Children and Adolescents with Refractory Solid Tumors. Canc Res 44: 3109–3113

    CAS  Google Scholar 

  10. Slevin ML (1991) The Clinical Pharmacology of Etoposide. Cancer 67 (Suppl): 319–329

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Boos, J. (1994). Clinical Pharmacokinetics of VP-16 — Special Aspects in Children. In: Büchner, T., Hiddemann, W., Wörmann, B., Schellong, G., Ritter, J. (eds) Acute Leukemias IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78350-0_27

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78350-0_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78352-4

  • Online ISBN: 978-3-642-78350-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics