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Lymphocyte Subsets and IL-1 Production in Children with Acute Lymphoblastic Leukemia During Intensive Chemo- and Radiotherapy

  • Conference paper
Acute Leukemias IV

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 36))

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Abstract

We have previously reported an apparent deficiency of interleukin-l (Il-1) production and impaired activity of natural killer cells during the entire period of cytostatic therapy in children with acute lymphoblastic leukemia (ALL) [1,2]. As Il-1, a multifaceted cytokine, acts directly on many immunocompetent cells, we were interested whether a deficiency of Il-1 production might contribute to the proliferation and distribution of lymphocyte subsets [3,−6]. Il-1 acts through receptors found on many cell types including T and B lymphocytes and natural killer (NK) cells [7,8].

The work was supported by grant of K.B.N. GR-3/91

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References

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Author information

Authors and Affiliations

  1. Department of Children Hematology and Oncology, Medical Academy, Wroclaw, Poland

    A. Chybicka & W. Jaworski

  2. Department of Children Surgery, Medical Academy, Wroclaw, Poland

    J. Boguslawska-Jaworska

Authors
  1. A. Chybicka
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  2. J. Boguslawska-Jaworska
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  3. W. Jaworski
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Germany

    T. Büchner

  2. Department of Pediatrics, University of Münster, Albert-Schweitzer-Strasse 33, 48145, Münster, Germany

    G. Schellong  & J. Ritter  & 

  3. Department of Internal Medicine, University of Göttingen, Robert-Koch-Strasse 40, 37075, Göttingen, Germany

    W. Hiddemann  & B. Wörmann  & 

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© 1994 Springer-Verlag Berlin Heidelberg

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Chybicka, A., Boguslawska-Jaworska, J., Jaworski, W. (1994). Lymphocyte Subsets and IL-1 Production in Children with Acute Lymphoblastic Leukemia During Intensive Chemo- and Radiotherapy. In: Büchner, T., Hiddemann, W., Wörmann, B., Schellong, G., Ritter, J. (eds) Acute Leukemias IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78350-0_22

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  • DOI: https://doi.org/10.1007/978-3-642-78350-0_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78352-4

  • Online ISBN: 978-3-642-78350-0

  • eBook Packages: Springer Book Archive

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