Clinical Applications of Stromal Cell Studies in Acute Leukemia
It is well-known that stromal cells have a crucial role in the regulation of hematopoiesis and engraftment . Stromal cell studies became even more attractive after the c-kit ligand (stem cell factor) was discovered [2,3]. Data dealing with the biological properties of stromal cells in malignant hematological disorders are still scarce, however. The aim of this study is to evaluate the influence of bone marrow fibroblastand stormal cell-conditioned medium (CM of patients with acute leukemia (AL) on the proliferation and differentiation of normal and leukemic cells with respect to the development of potential diagnostic and prognostic markers.
KeywordsAgar Tyrosine Leukemia Hydrocortisone Cyclophosphamide
Unable to display preview. Download preview PDF.
- 1.Eaves C (1990) Future uses of growth factors to improve the treatment of leukemia using strategies that require haematological rescue. In: Metcalf D, Borden EC (eds) Therapeutic strategies in oncology. Haemopoietic growth factors and the treatment of myeloid leukemia. London p. 27–56Google Scholar
- 2.Zsebo KM, Williams DA, Geissler EN, Broudy VC, Martin FH, Atkins HL, Hsu RY, Birkett NC, Okino KH, Murdock DC, Jacobsen FW, Langley KE, Smith KA, Takeishi T, Cattanach BM, Galli SJ, Suggs SV (1990) Stem cell factor is encoded at the Sl locus of the mouse and its ligand for the c-kit tyrosine receptor. Cell 63: 213PubMedCrossRefGoogle Scholar
- 3.Nocka K, Buck J, Levi E, Besmer P (1990) Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors. EMBO J 9: 3227Google Scholar
- 4.Zaritskey A Yu (1990) Bone marrow fibroblast colony formation in plasma clot (In Russian). Bull Exp Biol Med 110(7): 140–142Google Scholar