Clinical Applications of Stromal Cell Studies in Acute Leukemia

  • A. Yu. Zaritskey
  • O. V. Strijak
  • L. S. Zubarovskaya
  • K. V. Efimov
  • B. V. Afanasiev
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 36)

Abstract

It is well-known that stromal cells have a crucial role in the regulation of hematopoiesis and engraftment [1]. Stromal cell studies became even more attractive after the c-kit ligand (stem cell factor) was discovered [2,3]. Data dealing with the biological properties of stromal cells in malignant hematological disorders are still scarce, however. The aim of this study is to evaluate the influence of bone marrow fibroblastand stormal cell-conditioned medium (CM of patients with acute leukemia (AL) on the proliferation and differentiation of normal and leukemic cells with respect to the development of potential diagnostic and prognostic markers.

Keywords

Agar Tyrosine Leukemia Hydrocortisone Cyclophosphamide 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • A. Yu. Zaritskey
    • 1
  • O. V. Strijak
    • 1
  • L. S. Zubarovskaya
    • 1
  • K. V. Efimov
    • 1
  • B. V. Afanasiev
    • 1
  1. 1.Bone Marrow Transplantation Centre, City Hospital n 31, Institute of Oncology1st Pavlov Medical InstituteSt. PetersburgRussia

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