Abstract
The intercellular adhesion molecule-1 (ICAM-1) belongs to the immunoglobulin supergene family and is found to be expressed on a variety of hematopoietic and non-hematopoietic cells [1]. ICAM-1 is a ljgand for the LFA-1 adhesion receptor mediating LFA-1 dependent cell-cell interactions important for lymphocyte trafficking into inflammatory sites [2]. The expression of ICAM-1 can be modulated by inflammatory cytokines [3]. Precursor B-cell development involves a stroma-cell dependent phase in an early stage of pre B-ALL proliferation [4, 5]. During this early stage of development adhesion molecules like ICAM-1, LFA-1 VCAM-1 and VLA-4 might therefore play an essential role for the regulation and development ofleukemic progenitor cells [6]. We therefore investigated the expression and regulation of ICAM-1 by different cytokines which might play a role for the stroma dependent phase of precursor B-cell development.
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© 1994 Springer-Verlag Berlin Heidelberg
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Schardt, C., Schardt, C., Drexler, H.G., Ganser, A., Hoelzer, D. (1994). Regulation of the Expression of ICAM-1 on Pre-B Cell Lines by TNF-α and IFN-γ. In: Büchner, T., Hiddemann, W., Wörmann, B., Schellong, G., Ritter, J. (eds) Acute Leukemias IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78350-0_15
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DOI: https://doi.org/10.1007/978-3-642-78350-0_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-78352-4
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