Advertisement

Once Daily Dosing of Netilmicin in the Empirical Treatment of Fever in the Neutropenic Patient

  • E. Rozdzinski
  • W. Kern
  • A. Reichle
  • T. Moritz
  • T. Schmeiser
  • E. Kurrle
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 36)

Abstract

The combination of aminoglycosides with betalactams is frequently used as empirical therapy for serious infections in neutropenic patients. The dosing regimens for aminoglycosides usually include thrice or twice daily divided dosing. Recent experimental and clinical studies have suggested that once daily administration of aminoglycosides may be similar or less toxic and slightly more or as effective as the conventional thrice daily divided dosing. The human trials that have been published so far included only very few or no neutropenic patients at all. In the present study we evaluated the safety and efficacy of a once daily dosing regimen of netilmicin in combination with betalactam antibiotics in the empirical treatment of febrile neutropenic patients.

Keywords

Empirical Treatment Neutropenic Patient Betalactam Antibiotic Febrile Neutropenic Patient Daily Dose Regimen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • E. Rozdzinski
    • 1
    • 2
    • 3
  • W. Kern
    • 1
    • 2
    • 3
  • A. Reichle
    • 1
    • 2
    • 3
  • T. Moritz
    • 1
    • 2
    • 3
  • T. Schmeiser
    • 1
    • 2
    • 3
  • E. Kurrle
    • 1
    • 2
    • 3
  1. 1.Medizinische Universitätsklinik und PoliklinikUlmGermany
  2. 2.Klinikum Rechts der IsarMünchenGermany
  3. 3.Tumorklinik IIEssenGermany

Personalised recommendations