Bone Marrow Transplantation from an Unrelated Donor: Experiences in Children

  • T. Klingebiel
  • R. Handgretinger
  • G. Ehninger
  • R. Dopfer
  • D. Niethammer
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 36)

Abstract

Allogeneic bone marrow transplantation (BMT) from an HLA identical sibling is in childhood a curative treatment option after a relapse of acute lymphoblastic leukemia (ALL) [1,2], in chronic phase chronic myelogenous leukemia (CML) [2,3], in juvenile chronic myelogenous leukemia (jCML) [4] and seems to be a possible curative treatment option after a relapse of acute myelogenous luekemia (AML) [2,5]. In severe aplastic anemia (SAA) BMT seems to be superior to other treatment modalities [6]. Therefore we decided to treat also children by allogeneic BMT suffering from these diseases, but missing an HLA identical sibling donor. In our group the first unrelated donor BMT in childhood had been performed in 1986 [5].

Keywords

Toxicity Leukemia Anemia Methotrexate Cyclosporine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • T. Klingebiel
    • 1
  • R. Handgretinger
    • 1
  • G. Ehninger
    • 2
  • R. Dopfer
    • 1
  • D. Niethammer
    • 1
  1. 1.Department of Pediatric Hematology/OncologyEberhard-Karls UniversityTübingenGermany
  2. 2.Department of Internal MedicineEberhard-Karls UniversityTübingenGermany

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