Abstract
Although major progress has been made in the treatment of acute lymphoblastic leukemia (ALL), still major challenges have to be met: (a) Relapse rates of about 25% in children and 40% in adults after successful induction therapy are observed [1,2]. (b) Therapy is associated with acute and chronic toxicity, of which the risk of secondary leukemia, growth and brain development retardation in children may be the most serious. Therefore, methods have to be established that allow stratification of patients for risk adapted therapy. On one hand, patients with high risk for relapse may profit from more aggressive therapy; on the other hand, intensity of therapy may be reduced in patients with a high chance of being cured by standard therapy.
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© 1994 Springer-Verlag Berlin Heidelberg
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Griesinger, F. et al. (1994). Characterization of Clonal Gene Rearrangements for the Detection of Residual Leukemic Disease in Acute Lymphoblastic Leukemia. In: Büchner, T., Hiddemann, W., Wörmann, B., Schellong, G., Ritter, J. (eds) Acute Leukemias IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78350-0_10
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DOI: https://doi.org/10.1007/978-3-642-78350-0_10
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