The Treatment of Acute Leukemia: Observations by a Marrow Transplanter
When I graduated from medical school in 1946 the diagnosis of leukemia was a sentence of death. There were two developments near the end of the 1940s which were destined to change this dismal outlook. The first was the demonstration by Farber et al.  that a remission could be induced in children with acute lymphoblastic leukemia (ALL) by the use of an anti-folic antimetabolite. The second was the demonstration by Jacobson et al.  that mice could be protected from otherwise lethal irradiation by shielding the spleen, an observation that eventually led to the recognition of the potential role of marrow transplantation in the treatment of leukemia.
KeywordsToxicity Leukemia Pneumonia Oncol Radioactive Isotope
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