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Acute Leukemias IV pp 1–5Cite as

The Treatment of Acute Leukemia: Observations by a Marrow Transplanter

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Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 36))

Abstract

When I graduated from medical school in 1946 the diagnosis of leukemia was a sentence of death. There were two developments near the end of the 1940s which were destined to change this dismal outlook. The first was the demonstration by Farber et al. [1] that a remission could be induced in children with acute lymphoblastic leukemia (ALL) by the use of an anti-folic antimetabolite. The second was the demonstration by Jacobson et al. [2] that mice could be protected from otherwise lethal irradiation by shielding the spleen, an observation that eventually led to the recognition of the potential role of marrow transplantation in the treatment of leukemia.

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References

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Author information

Authors and Affiliations

  1. Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, WA, 98104, USA

    E. D. Thomas

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  1. E. D. Thomas
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Germany

    T. Büchner

  2. Department of Pediatrics, University of Münster, Albert-Schweitzer-Strasse 33, 48145, Münster, Germany

    G. Schellong  & J. Ritter  & 

  3. Department of Internal Medicine, University of Göttingen, Robert-Koch-Strasse 40, 37075, Göttingen, Germany

    W. Hiddemann  & B. Wörmann  & 

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© 1994 Springer-Verlag Berlin Heidelberg

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Thomas, E.D. (1994). The Treatment of Acute Leukemia: Observations by a Marrow Transplanter. In: Büchner, T., Hiddemann, W., Wörmann, B., Schellong, G., Ritter, J. (eds) Acute Leukemias IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78350-0_1

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  • DOI: https://doi.org/10.1007/978-3-642-78350-0_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78352-4

  • Online ISBN: 978-3-642-78350-0

  • eBook Packages: Springer Book Archive

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