Ernährung der Mutter und Neuralrohrdefekte

  • T. K. A. B. Eskes
  • R. P. M. Steegers-Theunissen
Conference paper

Zusammenfassung

Fehlernährung der Mutter, insbesondere Vitaminmangel (Folsäure), spielt eine Rolle in der Pathogenese von Neuralrohrdefekten (NRD) (Anenzephalie, Spina bifida, Enzephalozele).

Es ist eindeutig bewiesen, daß die Wiederholungsrate und Inzidenz von NRD durch die Behandlung der Mutter mit 4 mg bzw. 0,8 mg Folsäure pro Tag in der präkonzeptionalen Periode bis zum Ende des 2. Schwangerschaftsmonats reduziert werden kann.

Kürzlich konnten wir zeigen, daß bei einer Untergruppe von Frauen, die ein Kind mit NRD geboren hatten, Homocysteinämie vorliegt. Dies könnte ein wichtiger Risikofaktor in der Pathogenese der NRD sein. Diese Frauen können durch einen Methionin-Belastungstest identifiziert werden. Beim Metabolismus von Homocystein sind Vitamine beteiligt, insbesondere Folsäure und Vitamin B12 (Remethylenierung). Diese Ergebnisse können zu einer spezifischen Vitamintherapie führen.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • T. K. A. B. Eskes
  • R. P. M. Steegers-Theunissen

There are no affiliations available

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