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ATP-Sensitive K+ Channel: Properties, Occurrence, Role in Regulation of Insulin Secretion

  • U. Panten
  • C. Schwanstecher
  • M. Schwanstecher
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 108 / 2)

Abstract

A K+ channel inhibited by cytosolic ATP (KATP channel) was first demonstrated in cardiac cells by Noma (1983). This channel is also inhibited by sulfonylureas, is highly K+ selective, and has a single channel conductance of 80 pS when measured in symmetrical high K+ solutions (Trube and Hescheler 1984; Kakei and Noma 1984; Belles et al. 1987). Noma’s discovery prompted the identification of a K+ channel with similar properties in pancreatic β-cells (Cook and Hales 1984; Ashcroft et al. 1984; Sturgess et al. 1985), skeletal muscle (Spruce et al. 1985, 1987; Woll et al. 1989), smooth muscle (Nelson et al. 1990; Kajioka et al. 1991) and nerve cells (Jonas et al. 1991; Politi and Rogawski 1991; Ohno-Shosaku and Yamamoto 1992). This chapter confines itself to this K+ channel, and we use the term KATP channel with this restriction. Other types of ATP-sensitive K+ channels have been found in various cells (Ashcroft and Ashcroft 1990). Several reviews concerning the KATP channel have been published during the recent years (Ashcroft 1988; Ashcroft and Rorsman 1991; Ashford 1990; Ashcroft and Ashcroft 1990; Rorsman and Trube 1990; Dunne and Petersen 1991; Nichols and Lederer 1991; Davies et al. 1991; Noma and Takano 1991; Panten et al. 1992; Ashcroft and Ashcroft 1992). Where appropriate, these reviews are cited to limit the primary references.

Keywords

KATP Channel RINm5F Cell Galanin Receptor Sulfonylurea Receptor Vertebrate Axon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • U. Panten
  • C. Schwanstecher
  • M. Schwanstecher

There are no affiliations available

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