Role of Nucleoside Diphosphate Kinase in G-Protein Action
Nucleoside diphosphate kinase (NDP kinase, EC 184.108.40.206.) is a ubiquitous enzyme which catalyzes a transfer of the terminal phosphate of 5′-triphosphate nucleotides to 5′-diphosphate nucleotides (Parks and Agarwal 1973). Under physiological conditions, NDP kinase works to form triphosphate nucleotide pools at the expense of ATP. The products of the enzyme reaction are widely utilized for syntheses of essential cellular compounds such as nucleic acids, proteins, polysaccharides, and lipids.
KeywordsHydrolysis Polysaccharide Adenosine Expense Leucine
Unable to display preview. Download preview PDF.
- Hirayama R, Sawai S, Takagi Y, Mishima Y, Kimura N, Shimada N, Esaki Y, Kurashima C, Utsuyama M, Hirokawa K (1991) Positive relationship between expression of anti-metastatic factor (nm23 gene product or nucleoside diphosphate kinase) and good prognosis in human breast cancer. J Natl Cancer Inst 83:1249–1250.PubMedCrossRefGoogle Scholar
- Kimura N, Johnson GS (1983) Increased membrane-associated nucleoside diphosphate kinase activity as a possible basis for enhanced guanine nucleotide-dependent adenylate cyclase activity induced by picolinic acid treatment of simian virus 40-transformed normal rat kidney cells. J Biol Chem 258:12609–12617.PubMedGoogle Scholar
- Parks RE Jr, Agarwal RP (1973) Nucleoside diphosphokinases. In: Boyer PD (ed) The enzymes, vol 8. Academic, New York pp 307–333.Google Scholar