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Regulation of Cell Growth and Proliferation by Go

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Book cover GTPases in Biology II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 108 / 2))

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Abstract

One function controlled by intercellular communication and cell surface signal transduction is the regulation of cellular growth and proliferation. Many proteins that regulate cellular growth are components of well-studied signal transduction pathways. Normal counterparts of most nonnuclear oncogene products function as ligands, receptors, or intracellular effectors of signaling pathways (Bishop 1991). The heterotimeric G-protein coupled pathway is one such signal transduction pathway utilized by several cellular mitogens (Pouyssegur 1990). The sensitivity of this mitogenic signaling to pertussis toxin in some systems indicates that members of the Gi/Go family may be involved. Studies in our laboratory have focused on developing an understanding a role for Go in regulating the entry into the cell cycle as well as cell proliferation. The implications of these studies are discussed here.

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Authors
  1. S. D. Kroll
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  2. R. Iyengar
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Editors and Affiliations

  1. Baylor College of Medicine, Department of Medicine Cell Biology and Experimental Therapeutics, Houston VA Medical Center, Room 3C-385, 2002 Holcombe Boulevard, Houston, TX, 77030, USA

    Burton F. Dickey M.D.

  2. Department of Cell Biology, Molecular Physiology and Biophysics, Medicine and Neurosciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    Lutz Birnbaumer Ph.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Kroll, S.D., Iyengar, R. (1993). Regulation of Cell Growth and Proliferation by Go . In: Dickey, B.F., Birnbaumer, L. (eds) GTPases in Biology II. Handbook of Experimental Pharmacology, vol 108 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78345-6_30

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  • DOI: https://doi.org/10.1007/978-3-642-78345-6_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78347-0

  • Online ISBN: 978-3-642-78345-6

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