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Neurobiology of Go

  • Chapter
GTPases in Biology II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 108 / 2))

Abstract

Go, the subscript standing for other (other than Gs and Gi, has several interesting features (for a review see Bockaert et al. 1990) (1) it is highly concentrated in brain (0.5 to 1% of membrane bound proteins), (2) it is present in most excitable cells including endocrine cells and skeletal muscle (Toutant et al. 1990), (3) some Go protein epitopes and the gene organization are almost similar in vertebrates and invertebrates (Homburger et al. 1987; Yoon et al. 1989), (4) one of the roles of Goα is to negatively couple some receptors to voltage-sensitive Ca++ channels (see Table 1), (5) in view of (a) the high content of Goα in brain tissues, (b) the close associations of Goα with cytoskeletal elements, including microtubules, actin fibers, cytoplasmic matrices (see chapter A, I, II), and growth cone structures (Strittmatter et al. 1990), (c) the differential expression of two splice variants of Go (Go1α and Go2α) during neuronal differentiation and neurite outgrowth (Brabet et al. 1990; Rouotet al. 1992), it is likely that Goα plays also a key structural role in neuronal cell architecture.

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Authors
  1. P. Brabet
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  2. V. Homburger
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  3. J. Bockaert
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Editors and Affiliations

  1. Baylor College of Medicine, Department of Medicine Cell Biology and Experimental Therapeutics, Houston VA Medical Center, Room 3C-385, 2002 Holcombe Boulevard, Houston, TX, 77030, USA

    Burton F. Dickey M.D.

  2. Department of Cell Biology, Molecular Physiology and Biophysics, Medicine and Neurosciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    Lutz Birnbaumer Ph.D.

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Brabet, P., Homburger, V., Bockaert, J. (1993). Neurobiology of Go . In: Dickey, B.F., Birnbaumer, L. (eds) GTPases in Biology II. Handbook of Experimental Pharmacology, vol 108 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78345-6_28

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