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GTPases in Biology II pp 387–400Cite as

Hormonal Regulation of Phospholipid Metabolism via G-proteins II: PLA2 and Inhibitory Regulation of PLC

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 108 / 2))

Abstract

Lipid derivatives play a major role as second messengers. A large body of evidence has accumulated on the mechanisms leading to their formation and on their role in cell regulation (reviewed in Dennis et al. 1991). They are formed by the action of different phospholipases (A2, C, D) acting on membrane phospholipids. Of particular physiological relevance has been the elucidation of the hormonal regulation of these enzymes. A large number of receptors for hormones and neurotransmitters are coupled to cellular phospholipases and regulate the cytosolic levels of second messengers such as Ca2+, diacylglycerol, inositol trisphosphate, and arachidonic acid. The activation of phospholipases can be indirectly induced by a receptormediated increase in cytosolic Ca2+, or it can be due to the activation of a heterotrimeric GTP-binding (G) protein directly coupled to the enzyme.

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  1. D. Corda
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Editors and Affiliations

  1. Baylor College of Medicine, Department of Medicine Cell Biology and Experimental Therapeutics, Houston VA Medical Center, Room 3C-385, 2002 Holcombe Boulevard, Houston, TX, 77030, USA

    Burton F. Dickey M.D.

  2. Department of Cell Biology, Molecular Physiology and Biophysics, Medicine and Neurosciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    Lutz Birnbaumer Ph.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Corda, D. (1993). Hormonal Regulation of Phospholipid Metabolism via G-proteins II: PLA2 and Inhibitory Regulation of PLC. In: Dickey, B.F., Birnbaumer, L. (eds) GTPases in Biology II. Handbook of Experimental Pharmacology, vol 108 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78345-6_25

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  • DOI: https://doi.org/10.1007/978-3-642-78345-6_25

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