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GTPases in Biology II pp 351–362Cite as

Functional Expression of Mammalian Receptors and G-Proteins in Yeast

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 108 / 2))

Abstract

Biologists studying G-protein-linked signal transduction pathways have used heterologous expression systems to make many important discoveries, including the molecular description of pharmacologically distinct subtypes of receptors, and the specificity with which receptors, G-proteins, and their effectors interact with one another. However, commonly used expression systems, including those employing Xenopus oocytes or transfected mammalian cell lines, pose limitations for basic and applied scientists alike. Such systems are not usually amenable to rigorous formal genetic analysis of signal transduction pathways, and they are costly to use as biological screening tools in drug discovery programs.

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Authors
  1. K. J. Blumer
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Editors and Affiliations

  1. Baylor College of Medicine, Department of Medicine Cell Biology and Experimental Therapeutics, Houston VA Medical Center, Room 3C-385, 2002 Holcombe Boulevard, Houston, TX, 77030, USA

    Burton F. Dickey M.D.

  2. Department of Cell Biology, Molecular Physiology and Biophysics, Medicine and Neurosciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    Lutz Birnbaumer Ph.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Blumer, K.J. (1993). Functional Expression of Mammalian Receptors and G-Proteins in Yeast. In: Dickey, B.F., Birnbaumer, L. (eds) GTPases in Biology II. Handbook of Experimental Pharmacology, vol 108 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78345-6_22

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  • DOI: https://doi.org/10.1007/978-3-642-78345-6_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78347-0

  • Online ISBN: 978-3-642-78345-6

  • eBook Packages: Springer Book Archive

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