Local Anaesthetics and Pain Management

  • M. J. Cousins


Local anaesthetics have been in use in various forms for over 100 years [1–10]. Over the last two decades, there has been a significant growth in the use of local anaesthetics to produce neural blockade for surgical procedures ranging from superficial plastic surgery to major upper abdominal and thoracic surgery. This growth has included the use of “adjunctive” regional anaesthesia for procedures carried out under general anaesthesia, with the aim of reducing the requirements for general anaesthetic agents, but also in order to permit a pain free emergence from anaesthesia. Quite recently it has become apparent that this practice has implications for the prevention of persistent post surgical pain. In other forms of acute pain such as obstetrical, post traumatic and burns, use of local anaesthetic techniques continues to grow and plays a key role.


Local Anaesthetic Sodium Channel Cancer Pain Lipid Solubility Liver Blood Flow 
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© Springer-Verlag Berlin Heidelberg 1993

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  • M. J. Cousins

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