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Arterielle Baro- und Chemorezeptorenreflexe bei Schlafapnoepatienten

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Zusammenfassung

Das vegetative Nervensystem regelt die Organfunktion des Körpers und kontrolliert sein inneres Milieu. Bei ihm lassen sich funktional afferente und efferente Schenkel der Reflexbögen unterscheiden. Afferente Fasern leiten z. B. die Reizungen der Mechano- und Chemorezeptoren aus Lunge und Gefäßsystem. Efferente Fasern versorgen die glatte Muskulatur der verschiedenen Organe wie das Gefäßsystem und die Herzfunktionen. An diesen Regelungen sind die Reflexe der Karotisbarorezeptoren sowie die der peripheren arteriellen Chemorezeptoren beteiligt. Sie gehören zu den am besten untersuchten autonomen Reflexen.

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Literatur

  1. Bannister RL, Ardill L, Fentem P, (1967) Defective autonomic control of blood vessels in idiopathic orthostatic hypotension. Brain 90: 725–745

    Article  PubMed  CAS  Google Scholar 

  2. Bevegard BS, Sheperd T, (1966) Circulatory effects of stimulating the carotid arterial stretch receptor in man at rest and during exercise. J Clin Invest 45: 132–142

    Article  PubMed  CAS  Google Scholar 

  3. Bilgutay AM, Bilgutay I, Lillehei CW, (1967) Baropacing. A new concept in the treatment of hypertension. In: Kezdi P, (ed) Baroreceptors and hypertension. New York, Pergamon Press, pp 425–437

    Google Scholar 

  4. Bilgutay AM, Lillehei CW, (1965) Treatment of hypertension with an implantable electronic device. J Am Med Assoc 191: 649–653

    CAS  Google Scholar 

  5. Borst C, Karemaker JM, Bouman LN, Dunning AJ, Schopman FJG, (1974) Optimal frequency of carotid sinus nerve stimulation in treatment of angina pectoris. Cardiovasc Res 8: 674–680

    Article  PubMed  CAS  Google Scholar 

  6. Braunwald E, Epstein SE, Glick G, Wechsler A, Braunwald NS, (1976) Relief of angina pectoris by electrical stimulation of the carotid sinus nerves. N Engl J Med 277: 1278–1283

    Article  Google Scholar 

  7. Braunwald E, Sobel BE, Braunwald NS, (1969) Treatment of paroxysmal supraventricular tachycardia by electrical stimulation. N Engl J Med 281: 885–887

    Article  PubMed  CAS  Google Scholar 

  8. Brest AN, Wiener L, Bachrach B, (1972) Bilateral carotid sinus nerve stimulation in the treatment of hypertension. Am J Cardiol 29: 821–825

    Article  PubMed  CAS  Google Scholar 

  9. Carlsten A, Folkow B, Grimby G, Hamberger CA, Thulesius O, (1958) Cardiovascular effects of direct stimulation of the carotid sinus nerves in man. Acta Physiol Scand 44: 138–145

    Article  PubMed  CAS  Google Scholar 

  10. Dunning AJ, (1971) Electrostimulation of the carotid sinus nerve in angina pectoris. Excerpta Med PhD Thesis, Amsterdam

    Google Scholar 

  11. Eastcott HH, Pickering GW, Rob CG, (1954) Reconstruction of internal carotid artery in a patient with intermittent attacts of hemiplegia. Lancet 2: 994–996

    Article  Google Scholar 

  12. Eckberg DL (1977) Adaptation of the human carotid baroreceptor cardiac reflex. J Physiol (Lond) 269: 579–589

    CAS  Google Scholar 

  13. Eckberg DL, Cavanaugh MS, Mark AL, Abboud FM, (1975) A simplified neck suction device for activation of carotid baroreceptors. J Lab Clin Med 85: 167–173

    PubMed  CAS  Google Scholar 

  14. Eckoldt K, (1990) Probleme und Ergebnisse der Analyse des Sinusrhythmus. In: Zwiener, Michalik, Eckoldt, Klossek, (Hrsg) Herzfrequenzvariabilität - Möglichkeiten zur Diagnostik neurologischer Erkrankungen. Hirzel, Leipzig, S 53–63

    Google Scholar 

  15. Ejnell H, Hedner J, Cathahl K, Seligren J, Wallin G, (1991) Increased sympathetic activity as possible etiology of hypertension and left ventricular hypertrophy in patients with obstructive sleep apnea. In: Peter JH, Penzel T, Podszus T, Wiehert P von, (eds) Sleep and health risk. Springer, Berlin Heidelberg New York Tokyo, pp 341– 347

    Chapter  Google Scholar 

  16. Ernsting J, Parry DJ, (1957) Some observations on the effects of stimulating the stretch receptors in the carotid artery of men. Abstract. J Physiol (Lond) 137: 45P– 46 P

    Google Scholar 

  17. Geha AS, Klaigner RE, Bane AE, (1974) Bilateral carotid sinus nerve stimulation in the treatment of angina pectoris. Angiology 25: 16–20

    Article  PubMed  CAS  Google Scholar 

  18. Guz A, Noble MIM, Widdicombe JG, Threnchard D, Mushin WW, Makey AR, (1966) The role of vagal and glossopharyngeal afferent nerves in respiratory sensation, control of breathing and arterial pressure regulation in conscious man. Clin Sci 30: 161–170

    PubMed  CAS  Google Scholar 

  19. Hering HE, (1927) Die Karotissinus Reflex auf Herz und Gefäße. Steinkopff, Leipzig

    Google Scholar 

  20. Kezdi P, (1954) Neurogenic hypertension in man in porphyria. Arch Intern Med 94: 122–130

    CAS  Google Scholar 

  21. Koch E, Mies H (1929) Chronischer arterieller Hochdruck durch experimentelle Dauerausschaltung der Blutdruckzügler. Krankheitsforschung 7: 241–256

    Google Scholar 

  22. Kunitomo F, Kimura H, Tatsumi K, Okita S, Tojima H, Kuriyama T, Honda Y, (1989) Abnormal breathing during sleep and chemical control of breathing during wakefulness in patients with sleep apnea syndrome. Am Rev Respir Dis 139: 164–169

    Article  PubMed  CAS  Google Scholar 

  23. Lahiri S, Hsiao C, Zhang R, Mokahi A, Nishino T, (1985) Peripheral chemoreceptors in respiratory oscillations. J Appl Physiol 58 (6): 1901–1911

    PubMed  CAS  Google Scholar 

  24. Lown B, Levine SA, (1961) The carotid sinus. Clinical value of its stimulation. Circulation 33: 766–789

    Google Scholar 

  25. Ludbrook J, Mancia G, Ferrari A, Zanchetti A, (1977) The variable pressure neck- chamber method for studying the carotid baroreflex in man. Clin Sci 53: 165–171

    CAS  Google Scholar 

  26. Mancia G, Mark AL, (1985) Arterial baroreflexes in humans. In: Handbook of Physiology. American Physiological Society, Washington, pp 755–789

    Google Scholar 

  27. Martin RJ, Pennock BE, Orr WC, Sanders ME, Roggers RE, (1980) Respiratory mechanics and timing during sleep in occlusive sleep apnea. J Appl Physiol 48: 432

    PubMed  CAS  Google Scholar 

  28. Moog R, (1986) Disturbances of the circadian system due to masking effects. In: Rensing L, Heiden U van der, Mackey MC, (eds) Temporal disorder in human oscillatory systems. Springer, Berlin Heidelberg New York Tokyo, pp 186–188

    Google Scholar 

  29. Neilly JB, Kribbs NB, Maislin G, Pack AI, (1992) Effects of selectice sleep deprivation on ventilation during recovery sleep in normal humans. J Appl Physiol 72 (1): 100–109

    PubMed  CAS  Google Scholar 

  30. Neufeld HN, Goor D, Nathan D, Fischler H, Yerusalmi S, (1965) Stimulation of the carotid baroreceptors using a radiofrequency method. Isr J Med Sci 1: 630–632

    PubMed  CAS  Google Scholar 

  31. Önal E, Lopata M, (1982) Periodic breathing and the pathogenesis of oclussive sleep apnea syndrom. Am Rev Respir Dis 126: 676

    PubMed  Google Scholar 

  32. Önal E, Burrows DL, Hart RH, Lopata M, (1986) Induction of periodic breathing during sleep causes upper airway obstruction in humans. J Appl Physiol 61: 1438

    PubMed  Google Scholar 

  33. O’Reegan RG (1977) Control of carotid body chemoreceptors by autonomic nerves. Ir J Med Sc 146: 199

    Article  Google Scholar 

  34. Przybylski J, (1981) Do arterial chemoreceptors play a role in the pathogenesis of hypertension? Med Hypotheses 7: 127–131

    Article  PubMed  CAS  Google Scholar 

  35. Przybylski J, (1978) Alveolar hyperventilation in young spontaneously hypertensive rats. IRSC Med Seien Cardiovasc Syst 6: 315

    Google Scholar 

  36. Rotem CE, (1974) Carotid sinus nerve stimulation in the management of intractable angina pectoris: four years of follow up. Can Med Assoc J 110: 258–288

    Google Scholar 

  37. Schwartz SL, Griffith LSC, (1967) Reduction of hypertension by electrical stimulation of the carotid sinus nerve. In: Kezdi, (ed) Baroreceptors and Hypertension. Pergamon Press, New York, pp 409–424

    Google Scholar 

  38. Solti F, Szabo Z, Kerkovits G, Buday G, Bodor E, Kalmar I, (1975) Baropacing of the carotid sinus nerve for treatment of „intractable“ hypertension. Z Kardiol 64: 368–374

    PubMed  CAS  Google Scholar 

  39. Tafil-Klawe M, Trzebski A, Klawe J, Palko, (1985) Augmented chemoreceptor reflex tonic drive in early human hypertension and in normotensive subjects with family background of hypertension. Acta Physiol Pol 36 (l): 51–58

    Google Scholar 

  40. Tafil-Klawe M, Raschke F, Becker H, Hein H, Peter JH, (1989) Untersuchungen zur Funktionsdiagnostik der Atmungsregulation bei Patienten mit obstruktivem Schlaf-Apnoe-Syndrom. Pneumologie 43: 572–575

    PubMed  Google Scholar 

  41. Tafil-Klawe M, Raschke F, Hildebrandt G, (1990) Functional asymmetry in carotid sinus cardiac reflexes in humans. Eur J Appl Physiol 60: 402–406

    Article  CAS  Google Scholar 

  42. Tafil-Klawe M, Raschke F, Becker H, Hein H, Stoohs R, Kublik A, Peter JH, Penzel T, Podszus T, Wiehert P von, (1991) Investigations of arterial baro- and chemoreflexes in patients with arterial hypertension and obstructive sleep apnea syndrom. In: Peter JH, Penzel T, Podszus T, Wiehert P von, (eds) Sleep and health risk. Springer, Berlin Heidelberg New York Tokyo, pp 319–334

    Chapter  Google Scholar 

  43. Thron HL, Brechmann W, Wagner J, Keller K, (1967) Quantitative Untersuchungen über die Bedeutung der Gefäßdehnungsrezeptoren im Rahmen der Kreislaufhomoiostase beim wachen Menschen. Pflügers Arch 293: 68–99

    Article  CAS  Google Scholar 

  44. Trzebski A, Raczkowska M, Kubin L, (1980) Influence of respiratory activity and hy- pocapnia on the carotid baroreflex in man. In: Slight P, (ed) Arterial baroreceptors and hypertension. Oxford University Press, Oxford, pp 282–290

    Google Scholar 

  45. Trzebski A, Tafil M, Zoitowski M, Przybylski J (1982) Increased sensitivity of the arterial chemoreceptors drive in young men mild hypertension. Cardiovasc Res 16: 163–172

    Article  PubMed  CAS  Google Scholar 

  46. Tuckman J, Slater S, Mendlowitz M, (1967) The role of the carotid sinus reflexes in the hemodynamic regulation in normotensive and hypertensive man. In: Kezdi P, (ed) Baroreceptors and hypertension. New York, Pergamon Press, pp 333–347

    Google Scholar 

  47. Vogel H, Moog R, Hildebrand G, Peter JH, (1993) Chronobiologische Aspekte des OSAS. In: Peter JH, Cassel W (Hrsg) Schlaf - Atmung - Kreislauf. Springer, Berlin Heidelberg New York Tokyo (im Druck)

    Google Scholar 

  48. Wade JG, Larson CP, Hickey RE, Ehrenfeld WK, Severinhaus JW, (1970) Effects of carotid endarterectomy on carotid chemoreceptor and baroreceptor function in man. N Engl J Med 282: 823–829

    Article  PubMed  CAS  Google Scholar 

  49. Warner G, Skatrud JB, Dempsey JA, (1987) Effect of hypoxia induced periodic breathing on upper airway obstruction during sleep. J Appl Physiol 62 (6): 2201

    PubMed  CAS  Google Scholar 

  50. Weil JV, Byrne-Quinn E, Sodal JE, Friesen WO, Underhill B, Filley GH, Grover RT, (1970) Hypoxic ventilatory drive in normal men. J Clin Invest 49: 1061–1072

    Article  PubMed  CAS  Google Scholar 

  51. Weil JV, Byrne-Quinn E, Sodal JE, Filley GH, Grover RT (1971) Acquired attenualtion of chemoreceptor function in chronically hypoxic men at high altitude. J Clin Invest 50: 186–195

    Article  PubMed  CAS  Google Scholar 

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© 1993 Springer-Verlag Berlin Heidelberg

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Tafil-Klawe, M. et al. (1993). Arterielle Baro- und Chemorezeptorenreflexe bei Schlafapnoepatienten. In: Peter, J.H., Penzel, T., Cassel, W., von Wichert, P. (eds) Schlaf - Atmung - Kreislauf. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78303-6_12

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  • DOI: https://doi.org/10.1007/978-3-642-78303-6_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56837-7

  • Online ISBN: 978-3-642-78303-6

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