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AT-like Radiosensitive Rodent Cell Mutants: An Alternative Approach to the Isolation of the A-T Gene(s)

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Ataxia-Telangiectasia

Part of the book series: NATO ASI Series ((ASIH,volume 77))

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Abstract

Ataxia-telangiectasia (A-T) is a human autosomal recessive multisystem disorder characterized by progressive cerebellar ataxia, oculocutaneous telangiectasia, immunodeficiency, hypersensitivity to ionizing radiation and predisposition to cancer (for review see Sedgwick and Boder, 1991). Despite extensive investigation, the molecular defect responsible for these pleiotropic abnormalities in A-T remains unknown.

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Author information

Authors and Affiliations

  1. MGC-Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands

    M. Z. Zdzienicka, G. W. C. T. Verhaegh, W. Jongmans, N. G. J. Jaspers, M. Oshimura, M. R. James & P. H. M. Lohman

  2. J.A. Cohen Institute, Interuniversity Research Institute for Radiopathology and Radiation Protection, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands

    M. Z. Zdzienicka, G. W. C. T. Verhaegh, W. Jongmans, N. G. J. Jaspers, M. Oshimura, M. R. James & P. H. M. Lohman

  3. MGC-Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands

    N. G. J. Jaspers

  4. Department of Molecular and Cell Genetics, Tottori University, Japan

    M. Oshimura

  5. CEPH, Paris, France

    M. R. James

Authors
  1. M. Z. Zdzienicka
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  2. G. W. C. T. Verhaegh
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  3. W. Jongmans
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  4. N. G. J. Jaspers
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  5. M. Oshimura
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  6. M. R. James
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  7. P. H. M. Lohman
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Editor information

Editors and Affiliations

  1. Department of Pathology, University of California Los Angeles School of Medicine, Los Angeles, CA, 90024-6975, USA

    Richard A. Gatti

  2. Laboratory of Radiobiology and Environmental Health, University of California San Francisco, San Francisco, CA, 94143-0750, USA

    Robert B. Painter

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© 1993 Springer-Verlag Berlin Heidelberg

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Zdzienicka, M.Z. et al. (1993). AT-like Radiosensitive Rodent Cell Mutants: An Alternative Approach to the Isolation of the A-T Gene(s). In: Gatti, R.A., Painter, R.B. (eds) Ataxia-Telangiectasia. NATO ASI Series, vol 77. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78278-7_8

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  • DOI: https://doi.org/10.1007/978-3-642-78278-7_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78280-0

  • Online ISBN: 978-3-642-78278-7

  • eBook Packages: Springer Book Archive

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