Mammography Screening for A-T Heterozygotes
Swift et al (1992) have shown an increased incidence of breast cancer among A-T heterozygotes who had X-ray examinations five or more years prior to the diagnosis of the disease as compared to the incidence in the A-T heterozygotes who had not received such examinations. They assumed that the examinations were the cause for the increased incidence and suggested, therefore, that mammography screening may not be beneficial for A-T heterozygotes. We emphatically disagree: mammography screening is particularly beneficial for A-T heterozygotes whose risk for breast cancer is higher than for the general population.
KeywordsBreast Cancer Mammography Screening Natural Background Radiation Cellular Radiosensitivity Background Radiation Level
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- Cole J, Arlett CF, Green, MH et al (1988) Comparative human cellular radiosensitivity. II. The survival following gamma irradiation of unstimulated (Go) T-lymphocytes, T-lymphocyte lines, lympho-blastoid cell lines and fibroblasts from normal donors, from ataxia-telangiectasia patients and from ataxia-telangiectasia heterozygotes. Int J Radiat Biol 54: 929–943PubMedCrossRefGoogle Scholar
- National Research Council (1990) Health effects of exposure to low levels of ionizing radiation. BEIR V. National Academy Press, Washington, DCGoogle Scholar