Regulation of ras-Interacting Proteins in Saccharomyces cerevisiae
The environment surrounding cells of multicellular organisms is rich in nutrients; cells can easily take up nutrients available in special spaces such as blood vessels. However, these cells require growth factor(s) to start the cell division cycle. In contrast, in unicellular microorganisms such as yeast, nutrients themselves regulate cell growth. Yeast cells continue to divide as long as there is a sufficient supply of extracellular nutrients. In poor nutrient conditions, cells stop growing and arrest at the G1 phase of the cell cycle. The physiology of the G1 phase in nutrient-deprived conditions is apparently different from that of the G1 phase of growing cells. G1-arrested cells acquire resistance to environmental stress such as starvation or heat shock and become competent for the meiotic process.
KeywordsSaccharomyces Cerevisiae Adenylyl Cyclase GTPase Activate Protein CDC25 Gene Intrinsic GTPase Activity
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