Everywhere we look in biology, GTPases abound. Although the first examples appeared in apparently unrelated contexts — protein synthesis, cancer, hormone action, vision — we now recognize GTPases as members of a large superfamily, encoded by genes apparently descended from a single progenitor. The ability of a primordial GTPase to oscillate between GTP-and GDP-bound conformations furnished an opportunity for evolution to elaborate a diverse and versatile panoply of regulatory switches.
KeywordsGuanine Nucleotide Signal Recognition Particle GTPase Domain Ribosomal Protein Synthesis GTPase Superfamily
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