GTPases Everywhere!

  • H. R. Bourne
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 108 / 1)


Everywhere we look in biology, GTPases abound. Although the first examples appeared in apparently unrelated contexts — protein synthesis, cancer, hormone action, vision — we now recognize GTPases as members of a large superfamily, encoded by genes apparently descended from a single progenitor. The ability of a primordial GTPase to oscillate between GTP-and GDP-bound conformations furnished an opportunity for evolution to elaborate a diverse and versatile panoply of regulatory switches.


Guanine Nucleotide Signal Recognition Particle GTPase Domain Ribosomal Protein Synthesis GTPase Superfamily 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1993

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  • H. R. Bourne

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