Abstract
Everywhere we look in biology, GTPases abound. Although the first examples appeared in apparently unrelated contexts — protein synthesis, cancer, hormone action, vision — we now recognize GTPases as members of a large superfamily, encoded by genes apparently descended from a single progenitor. The ability of a primordial GTPase to oscillate between GTP-and GDP-bound conformations furnished an opportunity for evolution to elaborate a diverse and versatile panoply of regulatory switches.
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© 1993 Springer-Verlag Berlin Heidelberg
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Bourne, H.R. (1993). GTPases Everywhere!. In: Dickey, B.F., Birnbaumer, L. (eds) GTPases in Biology I. Handbook of Experimental Pharmacology, vol 108 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78267-1_1
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DOI: https://doi.org/10.1007/978-3-642-78267-1_1
Publisher Name: Springer, Berlin, Heidelberg
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