Everywhere we look in biology, GTPases abound. Although the first examples appeared in apparently unrelated contexts — protein synthesis, cancer, hormone action, vision — we now recognize GTPases as members of a large superfamily, encoded by genes apparently descended from a single progenitor. The ability of a primordial GTPase to oscillate between GTP-and GDP-bound conformations furnished an opportunity for evolution to elaborate a diverse and versatile panoply of regulatory switches.
KeywordsHydrolysis Codon Superoxide Assure Polypeptide
Unable to display preview. Download preview PDF.
- Mizuno T, Kaibuchi K, Ando S, Musha T, Hiraoka K, Takaishi K, Asada M, Nunoi H, Matsuda I, Takai Y (1992) Regulation of the superoxide-generating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins. J Biol Chem 267:10215–10218PubMedGoogle Scholar