Existence of a Chloride Pump in Molluscs

  • G. A. Gerencser
  • B. Zelezna
Part of the Advances in Comparative and Environmental Physiology book series (COMPARATIVE, volume 19)


The electrical activity of isolated epithelia has been a source of intense interest and much physiological study since the early reports of DuBois-Reymond (1848) and Galeotti (1904). However, it was not until the brilliant and innovative studies of Ussing and his collaborators (Ussing and Zerahn 1951) on frog skin in the mid 1950s and, later, those of Leaf (1965) and his co-workers on toad urinary bladder, that the nature of the bioelectric potential across isolated epithelia was defined. The defined interrelationship between bioelectric potential and active Na+ transport ushered in the modern era of the study of ion transport by epithelia. Skou (1965) defined in molecular terms the nature of Na+ transport with his ingenious work on the (Na+ + K+)-stimulated ATPase enzyme. For years thereafter, active Na+ transport across epithelia was intensively studied, with Cl assuming a secondary role of passive counter-ion. However, within the past 10–15 years there has been an explosive interest in transepithelial Cl movement, primarily because Cl has been found to be moved actively in a wide range of species (Frizzell et al. 1979; Gerencser 1983a, 1986; Gerencser et al. 1988).


ATPase Activity Choline Chloride Frog Skin Absorptive Cell Chloride Transport 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • G. A. Gerencser
    • 1
  • B. Zelezna
    • 1
  1. 1.Department of Physiology, College of MedicineUniversity of FloridaGainesvilleUSA

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