Chloride Transport by Gastric Mucosa

  • J. G. Forte
  • W. W. Reenstra
Part of the Advances in Comparative and Environmental Physiology book series (COMPARATIVE, volume 19)

Abstract

The vertebrate gastric mucosa is an electrically polarized epithelium that, under appropriate conditions, can generate an electrogenic current of Cl or H+ ions. Both ions are actively transported from the serosal to the mucosal side of the epithelium. The cell responsible for all the H+ transport and the vast majority of Cl transport is the oxyntic cell, a name deriving from its primary function, the secretion of isotonic hydrochloric acid (HC1). HC1 secretion is regulated by both neural and hormonal mechanisms that are closely tied to alimentation. Thus, the oxyntic cell has two physiological states, resting and stimulated, dependent on whether the cell has been activated to secrete HC1. While H+ secretion is limited to the stimulated state, Cl transport occurs in both states, although the rate is substantially increased by stimulation.

Keywords

Permeability Adenosine Histamine Luminal Omeprazole 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • J. G. Forte
    • 1
  • W. W. Reenstra
    • 2
  1. 1.Dept. of Molecular and Cell BiologyUniv. of CaliforniaBerkeleyUSA
  2. 2.Children’s Hospital Research InstitutueOaklandUSA

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