Activation and Inactivation of Adhesion Molecules

  • Y. van Kooyk
  • C. G. Figdor
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 184)


Immune surveillance is a major leukocyte function carried out by trafficking of leukocytes throughout the body. This constant recirculation between lymphoid organs and other tissues via lymph and blood implicates adhesion to the endothelial cell layer, migrating underneath the endothelial cells, degrading the basement membrane and penetrating the underlying tissue. Adhesion and migration of leukocytes is not a random process, but is orchestrated by a number of specialized adhesion receptors expressed at the cell surface of leukocytes and endothelial cells. Important questions that arise from these observations are: What cell surface structures determine lymphocyte homing or adhesion and migration of lymphocytes into inflamed tissue and, more importantly, how is this process regulated? Several receptors and counter receptors (adhesion pairs) which mediate binding between lymphocytes and endothelial cells have now been characterized. Molecular cloning of the genes encoding these cell surface structures has led to the discovery of distinct groups of structurally related proteins (Springer 1990).


Adhesion Receptor Cell Surface Structure Leukocyte Integrin Affinity Modulation Human Platelet Plasma Membrane 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1993

Authors and Affiliations

  • Y. van Kooyk
    • 1
  • C. G. Figdor
    • 1
  1. 1.Division of ImmunologyThe Netherlands Cancer InstituteAmsterdamThe Netherlands

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