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Activation and Inactivation of Adhesion Molecules

  • Chapter
Adhesion in Leukocyte Homing and Differentiation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 184))

Abstract

Immune surveillance is a major leukocyte function carried out by trafficking of leukocytes throughout the body. This constant recirculation between lymphoid organs and other tissues via lymph and blood implicates adhesion to the endothelial cell layer, migrating underneath the endothelial cells, degrading the basement membrane and penetrating the underlying tissue. Adhesion and migration of leukocytes is not a random process, but is orchestrated by a number of specialized adhesion receptors expressed at the cell surface of leukocytes and endothelial cells. Important questions that arise from these observations are: What cell surface structures determine lymphocyte homing or adhesion and migration of lymphocytes into inflamed tissue and, more importantly, how is this process regulated? Several receptors and counter receptors (adhesion pairs) which mediate binding between lymphocytes and endothelial cells have now been characterized. Molecular cloning of the genes encoding these cell surface structures has led to the discovery of distinct groups of structurally related proteins (Springer 1990).

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Authors and Affiliations

  1. Division of Immunology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    Y. van Kooyk & C. G. Figdor

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  1. Y. van Kooyk
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  2. C. G. Figdor
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Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstr. 487, 4005, Basel, Switzerland

    Dominique Dunon Ph.D. , Charles R. Mackay Ph.D.  & Beat A. Imhof Ph.D. ,  & 

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© 1993 Springer-Verlag Berlin · Heidelberg

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van Kooyk, Y., Figdor, C.G. (1993). Activation and Inactivation of Adhesion Molecules. In: Dunon, D., Mackay, C.R., Imhof, B.A. (eds) Adhesion in Leukocyte Homing and Differentiation. Current Topics in Microbiology and Immunology, vol 184. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78253-4_19

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  • DOI: https://doi.org/10.1007/978-3-642-78253-4_19

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