CD44 and Other Cell Interaction Molecules Contributing to B Lymphopoiesis
The term “adhesion” seems much too narrow to describe the multifunctional molecules on which this book is based. In addition to mediating physical interactions, as the name suggests, they serve as receptors for cell-cell communication and in the binding of cells to the extracellular matrix. The distinction between cell adhesion molecules and growth factor receptors has become blurred by reports that the latter can immobilize cells. Moreover, the same, or closely related, molecules can serve different specialized functions in multiple tissues. Information is gradually accumulating about interaction molecules expressed in lymphohematopoietic tissues and to date none have been convincingly described which are restricted to those sites. Our experience with B lymphocyte precursors suggests that molecules critical for the formation and export of blood cells from bone marrow are closely related to those responsible for their recruitment from the bloodstream and migration within peripheral tissues. Like other cell adhesion molecules, they have the very interesting property of having multiple functional states, which are actively regulated by cells that express them. The emphasis of this review will be on studies which have implicated four cell adhesion/ interaction molecules in B lymphopoiesis.
KeywordsMigration Lymphoma Leukemia Bacillus Polypeptide
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