CD2-Dependence on the CD3-Zeta-Chain in T Cell Signalling — Shown by Inhibitory and Modifying Effects of Cholera Toxin
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T cells can be activated through the TCR/CD3 complex or, alternatively (Meuer’ 87), through the CD2 molecule. The TCR/CD3 complex consists of the α/β heterodimer (TCR) and the subunits γ, δ, ε and the ζ-ζ-homodimer (together CD3), ζ being the main signalling element with a long intracellular part (Irving’ 91). CD2 is a single chain, surface-associated glyco-protein with a molecular mass of 50 kD, expressed on all human thymocytes and mature T cells.
KeywordsJurkat Cell Cholera Toxin Human Thymocyte Cytoplasmatic Free Calcium Postnuclear Supernatant
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