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CD2-Dependence on the CD3-Zeta-Chain in T Cell Signalling — Shown by Inhibitory and Modifying Effects of Cholera Toxin

  • G. F. Böl
  • B. M. Haack
  • K. Resch
Conference paper
Part of the NATO ASI Series book series (volume 76)

Abstract

T cells can be activated through the TCR/CD3 complex or, alternatively (Meuer’ 87), through the CD2 molecule. The TCR/CD3 complex consists of the α/β heterodimer (TCR) and the subunits γ, δ, ε and the ζ-ζ-homodimer (together CD3), ζ being the main signalling element with a long intracellular part (Irving’ 91). CD2 is a single chain, surface-associated glyco-protein with a molecular mass of 50 kD, expressed on all human thymocytes and mature T cells.

Keywords

Jurkat Cell Cholera Toxin Human Thymocyte Cytoplasmatic Free Calcium Postnuclear Supernatant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • G. F. Böl
    • 1
  • B. M. Haack
    • 1
  • K. Resch
    • 1
  1. 1.Hannover Medical SchoolInstitute of Molecular PharmacologyHannover 61Germany

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