CD2-Dependence on the CD3-Zeta-Chain in T Cell Signalling — Shown by Inhibitory and Modifying Effects of Cholera Toxin

  • G. F. Böl
  • B. M. Haack
  • K. Resch
Conference paper
Part of the NATO ASI Series book series (volume 76)

Abstract

T cells can be activated through the TCR/CD3 complex or, alternatively (Meuer’ 87), through the CD2 molecule. The TCR/CD3 complex consists of the α/β heterodimer (TCR) and the subunits γ, δ, ε and the ζ-ζ-homodimer (together CD3), ζ being the main signalling element with a long intracellular part (Irving’ 91). CD2 is a single chain, surface-associated glyco-protein with a molecular mass of 50 kD, expressed on all human thymocytes and mature T cells.

Keywords

Hydrolysis Lymphoma Tyrosine Tated Triphosphate 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • G. F. Böl
    • 1
  • B. M. Haack
    • 1
  • K. Resch
    • 1
  1. 1.Hannover Medical SchoolInstitute of Molecular PharmacologyHannover 61Germany

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