Abstract
Based on their substrate specificity and on the effect of inhibitors and activators, four major families of Ser/Thr-specific protein phosphatases have been distinguished (Cohen, 1989; Bollen and Stalmans, 1992). One of these families, termed type-1 protein phosphatases (PP-1), comprises a group of enzymes that all contain an isoform of the same catalytic subunit. They differ, however, in their noncatalytic subunit(s), which determine the activity and subcellular location of the enzyme.
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References
Beullens M, Van Eynde A, Stalmans W, Bollen M (1992) The isolation of novel inhibitory polypeptides of protein phosphatase-1 from bovine thymus nuclei. J. Biol. Chem. 267:16538–16544.
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Bollen M, Beullens M, Van Eynde A, Stalmans W (1993) Identification and regulation of nuclear inhibitors of protein phosphatase-1. Adv. Protein Phosphatases 7, in press.
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© 1993 Springer-Verlag Berlin Heidelberg
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Van Eynde, A., Beullens, M., Bollen, M., Stalmans, W. (1993). Characterization of Novel Nuclear Inhibitors of Protein Phosphatase — 1. In: Heilmeyer, L.M.G. (eds) Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling. NATO ASI Series, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78247-3_36
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DOI: https://doi.org/10.1007/978-3-642-78247-3_36
Publisher Name: Springer, Berlin, Heidelberg
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