Mitogen-Activated Signalling Pathways
The purpose of this lecture was to introduce the topic of signalling pathways and some of the components which make up these pathways. Since both of these subjects will be covered in greater detail by individual speakers during the meeting, this lecture should be viewed as a preview. In brief, it will begin with a discussion of two types of receptors, one which contains an inherent tyrosine kinase activity (Yarden Y and Ullrich A, 1988; Ullrich A and Schlessinger J, 1990; Cantley LC et al., 1991) and a second set of receptors which are characterized by having seven transmembrane domains (Dohlmann HG et al., 1991; Battey JF et al., 1991; Vu T-KH et al., 1991; Rasmussen UB et al., 1991). I will largely restrict the tyrosine kinase receptor part of the lecture to the epidermal growth factor (EGF)-receptor (Ullrich A and Schlessinger J, 1990; Carpenter G and Cohen S, 1990), and the seven transmembrane receptor part to the bombesin receptor (Battey JF et al., 1991). Next, I will discuss the mechanisms which couple these receptors to signalling pathways (Cantley LC et al., 1991) and conclude by presenting a newly described family of mitogen-activated Ser/Thr kinases which propagate the mitogenic signal through phosphorylation of specific target proteins (Kozma SC and Thomas G, 1992).
KeywordsEpidermal Growth Factor Receptor Epidermal Growth Factor Receptor Kinase Autophosphorylation Site Bombesin Receptor Transmembrane Domain Receptor
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