Skip to main content

Part of the book series: NATO ASI Series ((ASIH,volume 76))

  • 59 Accesses

Abstract

The phosphoinositides phosphatidylinositol (PtdIns), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) establish a membrane localized signaling pathway, which ultimately leads to the generation of the second messengers inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and diacylglycerol by phospholipase C (PLC).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Caswell, A.H., Lau, Y.H. and Brunschwig, J.P. (1976) Ouabain-binding vesicles from skeletal muscle. Arch. Biochem. Biophys. 176, 417–430.

    Article  PubMed  CAS  Google Scholar 

  • Clarke, N.G. and Dawson, M.C. (1981) Alkaline O-N transacylation. A new method for the quantitative deacylation of phospholipids. Biochem. J. 195, 301–306.

    PubMed  CAS  Google Scholar 

  • Hidalgo, C. and Jaimovich, E. (1989), Inositol trisphosphate and excitation con-tractioncoupling. J. Bioenerg. Biomembr. 21, 267–281.

    Article  PubMed  CAS  Google Scholar 

  • Hannon, J.D., Lee, N.K.M, Yandong. C. and Blinks, J.R. (1992) Inositol trisphosphate (InsP3) causes contraction in skeletal muscle only under artificial conditions, evidence that Ca2+ release can result from depolarization of T-tubules. J. Musc. Res. Cell Mot. 13, 447–456.

    Article  CAS  Google Scholar 

  • Lagos, N. and Vergara, J. (1990) Phosphoinositides in frog skeletal muscle: a quantitative analysis. Biochim. Biophys. Acta 1043, 235–244.

    PubMed  CAS  Google Scholar 

  • Lanzetta, P.A., Alvarez, L.J., Reinach, P.S. and Candia, O.A. (1979) An improved assay for nanomolar amounts of inorganic phosphate. Anal. Biochem. 100, 95–97.

    Article  PubMed  CAS  Google Scholar 

  • Mayr, G.W. (1988) A novel metal-dye detection system permits picomolar-range h.p.l.c. analysis of inositol polyphosphates from non-radioactively labelled cell or tissue specimens. Biochem. J. 254, 585–591.

    PubMed  CAS  Google Scholar 

  • Mayr, G.W. and Thieleczek, R. (1991) Masses of inositol phosphates in resting and tetanically stimulated vertebrate skeletal muscles. Biochem. J. 280, 631–640.

    PubMed  CAS  Google Scholar 

  • Schacht, J. (1976) Extraction and purification of polyphosphoinositides. Meth. Enzymol. 72, 626–631.

    Article  Google Scholar 

  • Sun, G.Y., Lin, T.N. and Irvine, R.F. (eds) (1990) Separation of phosphoinositides and other phospholipids by high-performance thin-layer chromatography. Methods in Inositide Research, Raven Press New York, pp 153–158.

    Google Scholar 

  • Thieleczek, R., Mayr, G.W. and Brandt, N.R. (1989) Inositol polyphosphate-mediated repartitioning of aldolase in skeletal muscle. J. Biol. Chem. 264, 7349–7356.

    PubMed  CAS  Google Scholar 

  • Valdivia, C., Vaughan, D., Potter, B.V.L. and Coronado, R. (1992) Fast Release of 45Ca2+ induced by inositol 1,4,5-trisphosphate and Ca2+ in the sarcoplasmic reticulum of rabbit skeletal muscle: evidence for two types of Ca2+ release channels. Biophys. J. 61, 1184–1193.

    Article  PubMed  CAS  Google Scholar 

  • Varsanyi, M., Messer, M. and Brandt, N.R. (1989) Intracellular localization of inositol-pospholipid-metabolizing enzymes in rabbit fast-twitch skeletal muscle. Eur. J. Biochem. 179, 473–479.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Milting, H., Thieleczek, R., Heilmeyer, L.M.G. (1993). Phosphoinositides in Rabbit Skeletal Muscle Membranes. In: Heilmeyer, L.M.G. (eds) Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling. NATO ASI Series, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78247-3_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78247-3_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78249-7

  • Online ISBN: 978-3-642-78247-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics